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Name: Gil Castro

Office: I3.13

School Phone: +351 253 604 815

Email:

 

 

 

Keywords: Tuberculosis Cytokines Acquired immunity

About

Gil Castro´s , is an AssociateProfessor at the School of Health Science, University of Minho. Gil Castro´s main research interests are focused in the establishment of correlates of resistance/susceptibility in experimental infections by mycobacteria (namely Mycobacteriumtuberculosis and M. ulcerans).Gil Castro has published 55 peer-reviewed research articles and 2 reviews. His main Research Contributions includes:

  • elucidationof the role of IL-12 on the differentiation of Th1 type of responses followingexperimental infection by Mycobacteriumavium

  • identificationof SLAM as a specific marker of Th1 type of cells

  • applicationof anti-IL-10R mAb as an adjuvant to Th1 type of responses

  • elucidationof the role of the IL-23/IL-17 axis in lung pathology following BCGrevaccination

  • demonstrationthat Interferon-gamma (IFN-?) acts as a regulator of Th17 expansion in vivo.

  • demonstrationthat Mycobacterium tuberculosis strains signal differentially via TLRreceptors.

  • Identificationof specific populations of polyfunctional CD4 Th cells as correlates ofprotection following BCG vaccination


Projects

Dynamics of granuloma assembling (Leader) 

Genetic determinants of TB resistance: the IL-12 family of cytokines (Leader) 

Innate immunity & Inflammation: impact on the immune response to intracellular pathogens: (M. tuberculosis; Listeria; Klebsiella) (Leader) 

Computational Molecular Biology and Evolution of the Mycobacterium tuberculosis Complex  

Evaluation of immune-determinants associated with resistance/susceptibility to Paracoccidioides brasiliensis: a mouse model perspective  

Host pathogen interactions in Mycobacterium ulcerans infection - Buruli Ulcer  

Importance of Plasmodium falciparum ABC transporters in antimalarial drug resistance  

Lung development orchestration by tissue macrophages  

Modulating bacteriostasis in M. tuberculosis infection: impact of the microbiome  

Pathogen Diversity and Epitope-based Immunoinformatics in Tuberculosis  

Understanding BCG vaccination: Correlates of protection/pathology following infection with M. tuberculosis  

Selected Publications

Cruz A, Fraga AG, Fountain JJ, Rangel-Moreno J, Torrado E, Saraiva M, Pereira DR, Randall TD, Pedrosa J, Cooper AM, Castro AG. Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis. J Exp Med. 2010 Aug 2;207(8):1609-16. doi: 10.1084/jem.20100265. Epub 2010 Jul 12.

Osório, Nuno S., Fernando Rodrigues, Sebastien Gagneux, Jorge Pedrosa, Marta Pinto-Carbó, António G. Castro, Douglas Young, Iñaki Comas, and Margarida Saraiva. "Evidence for diversifying selection in a set of Mycobacterium tuberculosis genes in response to antibiotic and non-antibiotic related pressure." Molecular Biology and Evolution (2013) 30 (6): 1326-1336. doi: 10.1093/molbev/mst038

Silva JP, Gonçalves C, Costa C, Sousa J, Silva-Gomes R, Castro AG, Pedrosa J, Appelberg R, Gama FM. "Delivery of LLKKK18 loaded into self-assembling hyaluronic acid nanogel for tuberculosis treatment". J Control Release. 2016 Jun 1;235:112-124.

Moreira-Teixeira L, Sousa J, McNab FW, Torrado E, Cardoso F, Machado H, Castro F, Cardoso V, Gaifem J, Wu X, Appelberg R, Castro AG, O'Garra A, Saraiva M. Type I IFN Inhibits Alternative Macrophage Activation during Mycobacterium tuberculosis Infection and Leads to Enhanced Protection in the Absence of IFN-gamma Signaling. J Immunol. 2016 Dec 15;197(12):4714-4726.

Nobrega C, Roque S, Nunes-Alves C, Coelho A, Medeiros I, Castro AG, Appelberg R, Correia-Neves M. Dissemination of mycobacteria to the thymus renders newly generated T cells tolerant to the invading pathogen. J Immunol. 2010 Jan 1;184(1):351-8. doi: 10.4049/jimmunol.0902152. Epub 2009 Nov 30.

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