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Name: Alexandra Gabriel Fraga

Office: I3.02

School Phone: +351 253 604 834

Email: afraga@med.uminho.pt

 

 

 

Keywords: Mycobacterium ulcerans Buruli ulcer Immunology Biosafety Level 3

About

Alexandra Fraga holds a degree in Applied Biology and a PhD in Health Sciences. She is currently a post-doc researcher at the Life and Health Sciences Research Institute, University of Minho. Her research activities have focused on the immune response against infections by virulent mycobacteria, namely Mycobacterium ulcerans, the causative agent of Buruli ulcer, and Mycobacterium tuberculosis, the agent of tuberculosis. Presently she is involved in studying the cellular and molecular mechanisms of host protection/susceptibility during infection and also in evaluating new strategies that aim at the modulation of the host response (e.g. vaccine design).

She has experience in working with different animal models of infection (mainly the mouse and guinea-pig model) and in vitro models of infection. She is also the Biosafety Coordinator of the Biosafety Level 3 Laboratories at the ICVS.

Projects

Host pathogen interactions in Mycobacterium ulcerans infection - Buruli Ulcer  

Nanomedicine/drug delivery systems to treat mycobacteriosis  

Selected Publications

Cruz A, Fraga AG, Fountain JJ, Rangel-Moreno J, Torrado E, Saraiva M, Pereira DR, Randall TD, Pedrosa J, Cooper AM, Castro AG. Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis. J Exp Med. 2010 Aug 2;207(8):1609-16. doi: 10.1084/jem.20100265. Epub 2010 Jul 12.

Torrado E, Fraga AG, Logarinho E, Martins TG, Carmona JA, Gama JB, Carvalho MA, Proença F, Castro AG, Pedrosa J. IFN-gamma-dependent activation of macrophages during experimental infections by Mycobacterium ulcerans is impaired by the toxin mycolactone. J Immunol. 2010 Jan 15;184(2):947-55. doi: 10.4049/jimmunol.0902717. Epub 2009 Dec 11.

Martins TG, Trigo G, Fraga AG, Gama JB, Longatto-Filho A, Saraiva M, Silva MT, Castro AG, Pedrosa J. Corticosteroid-induced immunosuppression ultimately does not compromise the efficacy of antibiotherapy in murine Mycobacterium ulcerans infection. PLoS Negl Trop Dis. 2012;6(11):e1925. doi: 10.1371/journal.pntd.0001925. Epub 2012 Nov 29.

Fraga AG, Cruz A, Martins TG, Torrado E, Saraiva M, Pereira DR, Meyers WM, Portaels F, Silva MT, Castro AG, Pedrosa J. Mycobacterium ulcerans triggers T-cell immunity followed by local and regional but not systemic immunosuppression. Infect Immun. 2011 Jan;79(1):421-30. doi: 10.1128/IAI.00820-10. Epub 2010 Oct 25.

Fraga AG, Martins TG, Torrado E, Huygen K, Portaels F, Silva MT, Castro AG, Pedrosa J. Cellular immunity confers transient protection in experimental Buruli ulcer following BCG or mycolactone-negative Mycobacterium ulcerans vaccination. PLoS One. 2012;7(3):e33406. doi: 10.1371/journal.pone.0033406. Epub 2012 Mar 8.

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