about icvs | People | ANDREIACARVALHO


Name: Andreia Carvalho

Office: I2.03

School Phone: +351 604 835

Email: andreiacarvalho@med.uminho.pt




Keywords: Ataxin-3 neurodegeneration Machado-Joseph disease splicing proteomics microarrays electrophysiology neuronal function cellular models C. elegans mouse models


Andreia Carvalho is a post doc at ICVS/3B’s PT-Government Associate Laboratory, at the School of Health Science, University of Minho. Her main line of research is related with the study of the physiological role of the protein involved in the neurodegenerative disorder Machado-Joseph disease (MJD), called ataxin-3. Her studies have been particularly focused on the function of ataxin-3 in neuronal cells and She is trying to establish a link between the normal function of the protein and the pathogenic mechanism of the disease. She has also been involved in other projects and studies, namely the study of pain perception in a tau knockout mouse model, the characterization of the secretome of MSCs and several pre-clinical trials.

More recently, She is interested in study the neuronal function in health and disease, by performing morphological and functional studies, such as electrophysiology.


Pathogenesis and Therapeutics of Machado-Joseph disease  

Selected Publications

Chatterjee A, Saha S, Silva-Fernandes A, Mandal SM, Neves-Carvalho A, Liu Y, Pandita RK, Chakraborty A, Hegde ML, Hegde PM, Boldogh I, Ashizawa T, Koeppen AH, Pandita TK, Maciel P, Sarkar P, Hazra TK. The role of the mammalian DNA end-processing enzyme polynucleotide kinase 3'-phosphatase in spinocerebellar ataxia Type 3 pathogenesis. PLoS Genetics, 29;11(1):e1004749 (2015).

Teixeira-Castro A, Ailion M, Jalles A, Brignull HR, Vilaça JL, Dias N, Rodrigues P, Oliveira JF, Neves-Carvalho A, Morimoto RI, Maciel P. Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans: rescue by the DAF-16 and HSF-1 pathways. Hum Mol Genet. 2011 Aug 1;20(15):2996-3009. doi: 10.1093/hmg/ddr203. Epub 2011 May 5.

Rodrigues AJ, Neves-Carvalho A, Teixeira-Castro A, Rokka A, Corthals G, Logarinho E, Maciel P. Absence of ataxin-3 leads to enhanced stress response in C. elegans. PLoS One. 2011 Apr 19;6(4):e18512. doi: 10.1371/journal.pone.0018512.

Esteves S, Duarte-Silva S, Neves-Carvalho A, Teixeira-Castro A, Oliveira P, Silva-Fernandes A, Maciel P. Limited effect of chronic valproic acid treatment in a mouse model of Machado-Joseph disease. PLOS One, 10(10):e0141610 (2015)

Sotiropoulos I, Lopes A, Pinto V, Lopes S, Carlos S, Duarte-Silva S, Neves-Carvalho A, Pinto-Ribeiro F, Pinheiro S, Fernandes R, Almeida A, Sousa N, Leite-Almeida H. Selective impact of Tau loss on nociceptive primary afferents and pain sensation. Exp Neurol, 261:486-493 (2014).

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