about icvs | People | CARLOSBESSA


Name: Carlos Bessa

Office: I2.13

School Phone: +351 253 604 875

Email: carlosbessa@med.uminho.pt






Carlos Bessa is a biologist with a PhD in biomedical sciences. His is currently working in using the nematode C. elegans to study genes involved in neurodevelopment, with the goal to understand the mechanisms/pathways that may lead to disease in humans. During his PhD, his studies focused on a rare group of neurodegenerative disorders, Neuronal Ceroid Lipofuscinosis, from a cell/molecular biology approach, looking at the mechanisms and effects of human mutations at a celular level.


Clinical and Genetic studies of human neurodevelopmental disorders  

Selected Publications

Bessa C, Maciel P, Rodrigues AJ. Using C. elegans to decipher the cellular and molecular mechanisms underlying neurodevelopmental disorders. Mol Neurobiology, in press.

Wen J*, Lopes F*, Soares G, Farrell SA, Nelson C, Qiao Y, Martell S, Badukke C, Bessa C, Ylstra B, Lewis S, Isoherranen N, Maciel P, Rajcan-Separovic E. Phenotypic and functional characterization of a recurrent microdeletion involving the 2p13.2 region. Orphanet J Rare Diseas, 8(1):100 (2013).

Teixeira-Castro A*, Jalles AL*, Esteves S*, Kang S, Santos L, Silva-Fernandes A, Neto M, Brielmann RM, Bessa C, Miranda A, Oliveira S, Neves-Carvalho A, Bessa J, Summavielle T, Silvermann RB, Oliveira P, Morimoto RI, Maciel P. Serotonergic signaling suppresses ataxin-3 aggregation and neurotoxicity in animal models of Machado-Joseph disease. Brain, 138(Pt 11):3221-3237 (2015).

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