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Name: Fernanda Marques

Office: I2.02

School Phone: +351 253 604 839

Email: fmarques@med.uminho.pt

 

 

 

Keywords: Brain barriers Choroid plexus Multiple sclerosis Alzheimer disease Aging Cerebrospinal fluid immune cell migration Lipocalin 2.

About

Fernanda Marques (FM) has obtained a BSc in Applied Biology [Universityof Minho (UM), 2001] and received her PhD in Health Sciences, in 2008, from the School of Health Sciences (ECS, UM). During her PhD, FM moved to Italy for characterization of the animal model of multiple sclerosis (MS), with Professor Francesca Aloisi (Department of Cell Biology and Neuroscience) and then to Los Angeles, for transcriptomic studies with Professor Daniel Geschwind(UCLA Neurogenetics Program, USA). As a postdoc, FM moved to Brazil where shereceived additional training in bioinformatic tools (provided by Professor HelenaBrentani, Cancer Hospital). During her career, FM significantly contributed to the neurosciences field showing that the choroid plexus (CP) [that is part ofthe barriers of the brain and the major site of cerebrospinal fluid (CSF)production] actively contributes to normal physiology.

Relevant publications: 

3.Marques F, Mesquita SD, Sousa JC, Coppola G, Gao F, Geschwind DH,Columba-Cabezas S, Aloisi F, Degn M, Cerqueira JJ, Sousa N, Correia-Neves M,Palha JA. Lipocalin 2 is present inthe EAE brain and is modulated by natalizumab. Front Cell Neurosci. 2012, 9;6:33.

4.Marques F, Sousa JC, Coppola G, Gao F, Puga R, Brentani H,Geschwind DH, Sousa N, Correia-Neves M, Palha JA. Transcriptome signature ofthe adult mouse choroid plexus. Front Cell Neurosci. 2012, 9;6:33.

CoppolaG, Geschwind DH,Sousa N, Palha JA, Correia-Neves M. The choroid plexus response to a repeatedperipheral inflammatory stimulus. BMC Neurosci. 2009, 18;10:135.

6.Marques F,Falcao AM, Sousa JC, Coppola G, GeschwindD, Sousa N, Correia-Neves M, Palha JA. Altered iron metabolism is part of the choroid plexusresponse to peripheral inflammation. Endocrinology2009, 150(6):2822-8.

7.Marques F, Sousa JC, Coppola G, Falcao AL, Rodrigues AJ, GeschwindDH, Sousa N, Correia-Neves M, Palha JA. Kinetic profile of the transcriptome changes induced in thechoroid plexus by peripheral inflammation. JCereb Blood Flow Metab. 2009, 29(5):921-32.

8.Marques F, Rodrigues AJ, Sousa JC, Coppola G, Geschwind DH,Correia-Neves M, Sousa N, Palha JA. Lipocalin2 is a choroid plexus acute phase protein. JCereb Blood Flow Metab. 2008, 28(3):450-5.

9.Marques F, Sousa JC, Correia-Neves M, Oliveira P, Sousa N, PalhaJA. The choroid plexus responseto peripheral inflammatory stimulus. Neuroscience2007, 144:424.

, M Correia-Neves, JC Sousa,N Sousa, JA Palha, 2011 Brain Barriers and the Acute-Phase Response, AcutePhase Proteins - Regulation and Functions of Acute Phase Proteins, InTech,Available from: http://www.intechopen.com/books/acute-phase-proteins-regulation-and-functions-of-acute-phase-proteins/brain-barriers-and-the-acute-phase-response.


Projects

Communication across the barriers (Leader) 

Multiple Sclerosis: Studying lipocalin 2 as a novel player in the pathophysiology of the disease (Leader) 

Impact of peripheral neuropathies on CNS function and structure  

Neural cells modulation and support  

Selected Publications

Lima A, Sardinha VM, Oliveira AF, Reis M, Mota C, Silva MA, Marques F, Cerqueira JJ, Pinto L, Sousa N, Oliveira JF. Astrocyte pathology in the prefrontal cortex impairs the cognitive function of rats. Mol Psych, 19:834-841

Oliveira TG, Chan RB, Bravo FV, Miranda A, Silva RR, Zhou B, Marques F, Pinto V, Cerqueira JJ, Di Paolo G, Sousa N. The impact of chronic stress on the rat brain lipidome. Mol Psych, 21(1):80-88 (2016).

Bessa JM, Ferreira D, Melo I, Marques F, Cerqueira JJ, Palha JA, Almeida OF, Sousa N. The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling. Mol Psychiatry. 2009 Aug;14(8):764-73, 739. doi: 10.1038/mp.2008.119. Epub 2008 Nov 4.

Ferreira AC, Mesquita SD, Sousa JC, Correia-Neves M, Sousa N, Palha JA, Marques F. From the periphery to the brain: lipocalin-2, a friend or foe? Prog Neurobiol, 131:120-136 (2015).

Mesquita SD, Ferreira AC, Sousa JC, Correia-Neves M, Sousa N, Marques F. "Insights on the pathophysiology of Alzheimer's disease: the crosstalk between amyloid pathology, neuroinflammation and the peripheral immune system". Neurosci Biobehav Rev. 2016 Jun 18;68:547-562.

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