Ricardo Silvestre concluded in 2003 his degree in Pharmaceutical Sciences in the Faculty of Pharmacy, University of Porto. It was in the same institution that in 2007 obtained his PhD in Biochemistry. His interest in Immunology and Parasitologyled him in 2003 to the Pasteur Institute in Paris where, as an undergraduate student, participated in studies on the antigenic variation and nucleararchitecture in the causative agent of human malaria, Plasmodium falciparum. During his PhD, he continued his studies in the field of Leishmania epigenetics,immune responses and attenuated Leishmania vaccine development. Between 2008 and 2010, he was a Postdoctoral research fellow at the Institut Mondor de Recherche Biomédicale (IMRB), University of Paris-Est Créteil, France, addressing the role of mitochondrial dynamics in regulating programmed cell death during HIV infection and anti-HIV chemotherapy. From 2010 to 2014, he held an assistant researcher position atthe Institute of Cell and Molecular Biology (IBMC), University of Porto, where he developed new approaches to understand the host immune mechanisms involvedin the control/susceptibility to leishmaniasis. Currently, he is PrincipaI Investigator at the Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho. His research interest is to integrate the study of basic molecular and cellular mechanisms to develop a greater understanding of the immune-metabolic interface in innate immune cells. He addresses how the modifications of host cell metabolism and bioenergetics arising during inflammatory or infectious processes impact the immune functions of monocytes/macrophage and dendritic cells and the further consequences to tissue homeostasis with the objective of developing new approaches to prevention and treatment.
Mesquita I, Varela P, Belinha A, Gaifem J, Laforge M, Vergnes B, Estaquier J, Silvestre R. "Exploring NAD+ metabolism in host-pathogen interactions". Cell Mol Life Sci (in press).
Moreira D, Silvestre R, Cordeiro-da-Silva A, Estaquier J, Foretz M, Viollet B. "AMPK as a target for pathogens: friends or foes?" Curr Drug Targets 2015 Apr 16. [Epub ahead of print]
Appelberg R, Moreira D, Barreira-Silva P, Borges M, Silva L, Dinis-Oliveira RJ, Resende M, Correia-Neves M, Jordan M, Ferreira N, Abrunhosa A, Silvestre R. "The Warburg effect in mycobacterial granulomas is dependent on the recruitment and activation of macrophages by gamma interferon". Immunology. 2015 Aug;145(4):498-507
Moukambi F, Rabezanahary H, Rodrigues V, Racine G, Robitaille L, Krust B, Andreani G, Soundaramourty C, Silvestre R, Laforge M, Estaquier J. "Early loss of splenic Tfh cells in SIV-infected rhesus macaques". PLoS Pathog. 2015 Dec 7;11(12):e1005287.
Laforge M, Rodrigues V, Silvestre R, Gautier C, Weil R, Corti O, Estaquier J. "NF-?B pathway controls mitochondrial dynamics". Cell Death Differ. 2016 Jan;23(1):89-98.