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Research & Scientists | Microbiology & Infection | People | MARIAVEIGA

 

Name: Maria Isabel Veiga

Office: I3.02

School Phone: +351 253 604 834

Email: mariaveiga@med.uminho.pt

 

 

 

Keywords: Malaria drug resistance transporters Plasmodium falciparum

About

Isabel Veiga holds a degree in Biotechnology Engineering and a PhD in Medical Sciences concluded in 2011 at Karolinska Institute, Stockholm, contributingto the knowledge on mechanism of drug resistance in the malaria parasite. In 2012, went to  Columbia University, New York as postdoctoral fellow to perform transfection-based studies validating field selected polymorphisms as reliable markers, important for early and accurate detection of resistance.

At present she is at ICVS, University of Minho continuing exploring the malaria parasite with new molecular approaches, defining molecular pathways that takes the parasite to the development of drug resistance. She is also working on drug development and novel malaria diagnostic tools.

Overall, published 25 papers evidencing a unique and translational approach tackling how the malaria parasite escapes the action of a therapeutic drug. Her work also contributes to reinforce the concept of malaria drug resistance as a multi-factorial and complex phenomenon that not only relates to the parasite’s handling of the incoming drug, but also concomitant responses of its basic physiology and human host factors.

International impact of her research can be accessed by the over 1000 citations and more than 100 co-authors with an h-index of 17, rendered into a strong collaborative network translated into funds and students overseas to proceed with post-graduation at the ICVS, UMinho.

In recognition of her work, she was awarded by L'Oréal Portugal/UNESCO in 2016 with Honor Medal for Women in Science and in 2018 by the Ministry of Higher Education, Science and Technology from Dominican Republic with “Act of Recognition and Award 2018” within the framework of the Career of Researchers in Science, Technology and Innovation. This year, she received a distinguished invitation bythe president of Ciência Viva, to be part of the 2nd edition of the book “Women in Science” that brings together over one hundred portraits ofPortuguese researchers.


Selected Publications

Silva M, Ferreira PE, Otienoburu SD, Calçada C, Ngasala B, Björkman A, Mårtensson A, Gil JP, Veiga MI. Plasmodium falciparum K13 expression associated with parasite clearance during artemisinin-based combination therapy. J Antimicrob Chemother. 2019 Mar 14. pii: dkz098. doi: 10.1093/jac/dkz098. [Epub ahead of print]

Inoue J, Silva M, Fofana B, Sanogo K, Mårtensson A,Sagara I, Björkman A, Veiga MI,Ferreira PE, Djimde A, Gil JP. Plasmodium falciparum Plasmepsin 2 Duplications, West Africa. Emerg Infect Dis. 2018 Aug 17;24(8). doi: 10.3201/eid2408.180370

Cruz M, Sánchez IM, Diaz J, Cuevas F, Silva M, DislaM, Ferreira PE, Veiga MI. Dosage of Single Low-Dose Primaquine to Stop MalariaTransmission. J Infect Dis. 2018 May5;217(11):1849-1850. doi: 10.1093/infdis/jiy108.

Vanaerschot M, Lucantoni L, Li T, Combrinck JM,Ruecker A, Kumar TRS, Rubiano K, Ferreira PE, Siciliano G, Gulati S, HenrichPP, Ng CL, Murithi JM, Corey VC, Duffy S, Lieberman OJ, Veiga MI, Sinden RE, Alano P, Delves MJ, Lee Sim K, Winzeler EA,Egan TJ, Hoffman SL, Avery VM, Fidock DA. Hexahydroquinolines are antimalarialcandidates with potent blood-stage and transmission-blocking activity. Nat Microbiol. 2017 Aug 14. doi:10.1038/s41564-017-0007-4.

Veiga MI,Dhingra, S.K.,Henrich, P.P., Straimer, J., Gnadig, N., Uhlemann, AC., Martin, R.E., Lehane,A.M., Fidock, D.A.. Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility toartemisinin-based combination therapies. NatureCommunications; 2016 May 18;7:11553.

Veiga MI, Osório NS, FerreiraPE, Franzén O, Dahlstrom S, Lum JK, Nosten F, Gil JP. Complex polymorphisms in the Plasmodium falciparumMultidrug Resistance Protein 2 gene and its contribution to antimalarialresponse. Antimicrob Agents Chemother. 2014Dec;58(12):7390-7. 

Projects

Defining redox pathways in antimalarial drug resistance (Leader) 

Detoxification mechanisms in Plasmodium falciparum malaria (Leader) 

Genetic determinants of malaria resistance in Dominican Republic (Leader) 

Importance of Plasmodium falciparum ABC transporters in antimalarial drug resistance (Leader) 

Computational Molecular Biology and Evolution of the Mycobacterium tuberculosis Complex  

Functional impact of allelic variants of metabolic genes under positive selection in the fitness of Mycobacterium tuberculosis  

Selected Publications

Veiga MI, Dhingra SK, Henrich PP, Straimer J, Gnadig N, Uhlemann AC, Martin RE, Lehane AM, Fidock DA. "Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies". Nat Commun. 2016 May 18;7:11553.

Veiga MI, Ferreira PE, Malmberg M, Jörnhagen L, Björkman A, Nosten F, Gil JP. pfmdr1 amplification is related to increased Plasmodium falciparum in vitro sensitivity to the bisquinoline piperaquine. Antimicrob Agents Chemother. 2012 Jul;56(7):3615-9. doi: 10.1128/AAC.06350-11. Epub 2012 Apr 16.

Vanaerschot M, Lucantoni L, Li T, Combrinck J, Ruecker A, Kumar TR, Rubiano K, Ferreira PE, Siciliano G, Gulati S, Henrich P, Ng C, Murithi J, Corey V, Duffy S, Lieberman O, Veiga MI, Sinden R, Alano P, Delves M, Sim KL, Winzeler E, Egan T, Hoffman SL, Avery V, Fidock D. "Hexahydroquinolines are Antimalarial Candidates with Potent Blood Stage and Transmission-Blocking Activity". Nat Microbiol. 2017 Oct;2(10):1403-1414.

Veiga MI, Osório NS, Ferreira PE, Franzén O, Dahlstrom S, Lum JK, Nosten F, Gil JP. Complex polymorphisms in the Plasmodium falciparum Multidrug Resistance Protein 2 gene and its contribution to antimalarial response. Antimicrob Agents Chemother. 2014 Sep 29. pii: AAC.03337-14. [Epub ahead of print]

Jovel IT, Ferreira PE, Veiga MI, Malmberg M, Mårtensson A, Kaneko A, Zakeri S, Murillo C, Nosten F, Björkman A, Ursing J. Single nucleotide polymorphisms in Plasmodium falciparum V type H+ pyrophosphatase gene (pfvp2) and their associations with pfcrt and pfmdr1 polymorphisms. Infect Genet Evol. 2014 Mar 20;24C:111-115. doi: 10.1016/j.meegid.2014.03.004

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