Research & Scientists | Microbiology & Infection | People | JULIASANTOS


Name: Júlia Santos

Office: I301

School Phone: +351 253 604 945

Email: juliasantos@med.uminho.pt






Júlia Santos (PhD, MScMicrobiology) is an Applied Biologist, graduated from the University of Minho, with a master’s degree in Molecular Microbiology and PhD in Health Sciences. During her PhD she characterized the cell death mechanisms and nutrient signaling pathways involved in Ammonium toxicity in aging yeast cells. She is currently a post-doc researcher at the Life and Health Sciences Research Institute at University of Minho. She has a backgroundin yeast molecular biology and cell physiology and her current research activities focus on the role of Ammonium as a key effector in the nutritional balance required for increased yeast longevity.


Ammonium toxicity in yeast: different culture conditions with different nitrogen sources  

Weak acid resistance in yeasts: better food preservative conditions and improvement of Saccharomyces cerevisiae fitness for industrial applications  

Selected Publications

Santos J, Sousa MJ, Leão C (2012) Ammonium Is Toxic for Aging Yeast Cells, Inducing Death and Shortening of the Chronological Lifespan. PLoS ONE 7(5): e37090. doi:10.1371/journal.pone.0037090

Santos J, Sousa MJ, Cardoso H, Inácio J, Silva S, Spencer-Martins I, Leão C. Ethanol tolerance of sugar transport and the rectification of stuck wine fermentations. Microbiology. 2008 Feb;154(Pt 2):422-30. doi: 10.1099/mic.0.2007/011445-0.

Mira NP, Münsterkötter M, Valada FD, Santos J, Palma M, Roque FC, Guerreiro JF, Rodrigues F, Sousa MJ, Leão C, Güldener U, Isabel Sá-Correia I. The genome sequence of the highly acetic acid-tolerant Zygosaccharomyces bailii derived interspecies hybrid strain ISA1307, isolated from a sparkling wine plant. DNA Res. 2014 Jan 21.

Santos J, Leão C, Sousa MJ. Ammonium-dependent shortening of CLS in yeast cells starved for essential amino acids is determined by the specific amino acid deprived, through different signaling pathways. Oxid Med Cell Longev. 2013;2013:161986. doi: 10.1155/2013/161986. Epub 2013 Aug 26.

Santos, J; Leitão-Correia, F; João Sousa, M; and Leão, C. 2014. Ammonium is a key determinant on the dietary restriction of yeast chronological aging in culture medium. Oncotarget. [Online] 5:0

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