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Research & Scientists | Neurosciences | People | ID4406

 

Name: Nuno Dinis Alves

Office: I2.02

School Phone: +351 253 604 839

Email: ID4406@alunos.uminho.pt

 

 

 

Keywords: Stress Adult Neural Plasticity Neurogenesis Dentate Gyrus Depression Antidepressants

About

Nuno Dinis Alves (29 years-old, PhD) is a research fellow at the Neuroscience Research Domain in the Life and Health Sciences Research Institute (ICVS), University of Minho (Portugal).

He is graduated in Biochemistry (2009) by the University of Trás-os-Montes e Alto Douro (UTAD, Vila Real) and Master in Cellular and Molecular Biology (2011) by the University of Coimbra. Nuno Dinis Alves has developed his master thesis in the department of Neuroscience of the Janssen Pharmaceutica (Belgium). Nuno performed his doctoral studies (2012-2017) supervised by Prof. Luísa Pinto and Professor Nuno Sousa.

Nuno is interested in the understanding of the involvement of adult hippocampal neurogenesis in behavioral settings and in the mechanisms behind the persistent effects of depression. Moreover, he is focus on the involvement of adult hippocampal neurogenesis in the therapeutical effects of antidepressants.

Nuno is member of the Junior Members Advisory Panel (JMAP) of the European College of Neuropsychopharmacology (ECNP).

RELEVANT PUBLICATIONS:


Alves ND*, Patricio P*, Correia JS, Mateus-Pinheiro A, Machado-Santos AR, Morais M, Bessa JM, Sousa N, Pinto L.  Chronic stress targets adult neurogenesis preferentially in the suprapyramidal blade of the rat dorsal dentate gyrus.
Brain Struct Funct, doi:10.1007/s00429-017-1490-3, 2017 *these authors contributed equally to this work.
 
Alves ND, Correia JS, Patricio P, Mateus-Pinheiro A, Machado-Santos AR, Morais M, Bessa JM, Sousa N, Pinto L.  Adult hippocampal neuroplasticity triggers susceptinility to recurrent depression.
Transl Psychiatry, doi:10.1038/tp.2017.29, 2017

Morais M, Patricio P, Mateus-Pinheiro A, Alves ND, Machado-Santos AR, Correia JS, Pereira J, Pinto L, Sousa N, Bessa JM.  The modulation of adult neuroplasticity is involved in the mood-improving actions of atypical antipsychotics in an animal model of depression.
Transl Psychiatry, 7(6), e1146 doi:10.1038/tp.2017.120, 2017

Mateus-Pinheiro A*, Alves ND*, Patricio P, Machado-Santos AR, Loureiro-Campos E, Silva JM, Sardinha VM, Reis, J, Schorle H, Oliveira JF, Ninkovic J, Sousa N, Pinto L.  AP2gamma controls adult hippocampal neurogenesis and modulates cognitive, but not anxiety or depressive-like behavior.
Molecular Psychiatry, doi:10.1038/mp.2016.169, 2016 *these authors contributed equally to this work.

Caetano L*, Pinheiro H*, Patrício P, Mateus-Pinheiro A, Alves ND, Henriques SN, Baptista FI, Cunha C, Machado-Santos AR, Ferreira SG, Sardinha VM, Oliveira JF, Ambrósio AF, Sousa N, Cunha RA, Rodrigues AJ, Pinto L*, Gomes CA*. Adenosine A2Areceptor regulation of microglia morphologic remodelling - gender bias in physiology and in a model of chronic anxiety.
Molecular Psychiatry, doi:10.1038/mp.2016.173, 
2016 *these authors contributed equally to this work.

Patrício P, Mateus-Pinheiro A, Irmler M, Alves ND, Machado-Santos AR, Morais M, Correia JS, Korostynski M, Piechota M, Stoffel R,Beckers J, Bessa JM, Almeida OF, Sousa N, Pinto L. Differential and Converging Molecular Mechanisms of Antidepressants' Action in the Hippocampal Dentate Gyrus. 
Neuropsychopharmacology, Jan 40(2):338-49 doi:10.1038/npp.2014.176, 2015

Mateus-Pinheiro A*, Patrício P*, Alves ND, Machado-Santos AR, Morais M, Bessa JM, Sousa N, Pinto L. The Sweet Drive Test: Refining phenotypic characterization of anhedonic behavior in rodents.
Front. Behav. Neurosc., 8:74. doi:10.3389/fnbeh.2014.00074, 2014 *these authors contributed equally to this work.


Mateus-Pinheiro A*, Pinto L*, Bessa JM, Morais M, Alves ND, Monteiro S, Patrício P, Almeida OF, Sousa N. Sustained remission from depressive-like behavior depends on hippocampal neurogenesis.
Transl Psychiatry Jan 15;3:e210. doi:10.1038/tp.2012.141, 2013 *these authors contributed equally to this work.

Selected Publications

Patrício P, Mateus-Pinheiro A, Irmler M, Alves ND, Machado-Santos AR, Morais M, Correia JS, Korostynski M, Piechota M, Stoffel R, Beckers J, Bessa JM, Almeida OF, Sousa N, Pinto L. Differential and converging molecular mechanisms of antidepressants action in the hippocampal dentate gyrus. Neuropsychopharmacology. 2015 Jan;40(2):338-49. doi: 10.1038/npp.2014.176. Epub 2014 Jul 18.

Mateus-Pinheiro A, Patrício P, Alves ND, Machado-Santos AR, Morais M, Bessa JM, Sousa N. Pinto L. The Sweet Drive Test: Refining phenotypic characterization of anhedonic behavior in rodents. Front Behav Neurosc, 8:74 (2014).

Mateus-Pinheiro A, Pinto L, Bessa JM, Morais M, Alves ND, Monteiro S, Patrício P, Almeida OFX and Sousa N. Sustained remission from depressive-like behavior depends on hippocampal neurogenesis. Transl Psychiatry, 3(1): e210 (2013).

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