Research & Scientists | Neurosciences | People | ANASOUSA


Name: Ana Luisa Jalles Monteiro de Sousa

Office: I2.03

School Phone: +351 253 604 835

Email: id3620@alunos.uminho.pt




Keywords: Machado-Joseph disease neurodegeneration aging proteostasis


I am a PhD student involved in the study of a neurodegenerative disorder denominated Machado-Joseph disease, the most common ataxia worldwide. I am focused in the study of the pathogenesis and development of therapeutic strategies using C. elegans as an animal model. 


Pathogenesis and Therapeutics of Machado-Joseph disease  

Selected Publications

Teixeira-Castro A, Ailion M, Jalles A, Brignull HR, Vilaça JL, Dias N, Rodrigues P, Oliveira JF, Neves-Carvalho A, Morimoto RI, Maciel P. Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans: rescue by the DAF-16 and HSF-1 pathways. Hum Mol Genet. 2011 Aug 1;20(15):2996-3009. doi: 10.1093/hmg/ddr203. Epub 2011 May 5.

Jalles A, Maciel P. The disruption of proteostasis in neurodegenerative diseases. AIMS Molecular Sciences, 2(3):259-293 (2015).

Teixeira-Castro A*, Jalles AL*, Esteves S*, Kang S, Santos L, Silva-Fernandes A, Neto M, Brielmann RM, Bessa C, Miranda A, Oliveira S, Neves-Carvalho A, Bessa J, Summavielle T, Silvermann RB, Oliveira P, Morimoto RI, Maciel P. Serotonergic signaling suppresses ataxin-3 aggregation and neurotoxicity in animal models of Machado-Joseph disease. Brain, 138(Pt 11):3221-3237 (2015).

Copyright © 2012-2016 ICVS. All rights reserved.