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Research & Scientists | Neurosciences | People | DIANAAMORIM

 

Name: Diana Alexandra da Silva Amorim

Office: I2.03

School Phone: +351 253 604 835

Email: dianaamorim@med.uminho.pt

 

 

 

Keywords: Pain facilitation Arthritis Diabetes Behaviour Electrophysiology

About

Diana Amorim is a biochemist, graduated by the University of Coimbra (2005-2008) and received her MSc in biochemistry by the University of Porto in 2010. In 2012, Diana moved (6 months) to the Institute of Biomedicine of the University of Helsinki to perform spinal cord electrophysiological recordings. In 2014, she finished her PhD degree in Health Sciences from the University of Minho.

She is experienced in rodent behaviour, intracerebral and intrathecal cannula implantation, pharmacology and electrophysiology.

The research in the neuroscience field began in her master thesis (2009) and her work is mainly focused on the role of the dorsomedial nucleus of the hypothalamus (DMH), the rostral ventromedial medulla (RVM) and the medullary dorsal reticular nucleus (DRt) upon nociceptive modulation, three brain areas involved in nociceptive facilitation.

Additionally, Diana Amorim is also studying the pain and mood disorders comorbidity in the kaolin and carrageenan (K/C) experimental model of monoarthritis and in the streptozotocin (STZ) model of diabetes.

And because the research work can not be done by a single person, Diana has the collaboration of:

Armando Almeida (supervisor), Filipa Pinto-Ribeiro (supervisor), Ana David-Pereira (works in the K/C model), Sónia Puga (works in the STZ model) and Patrícia Rebelo (works in the galanin role in the DMH)


Projects

Pain modulation in chronic pain syndromes and comorbid mood disorders  

Selected Publications

Amorim D, David-Pereira A, Marques P, Puga S, Rebelo P, Costa P, Pertovaara A, Almeida A, Pinto-Ribeiro F. A role of supraspinal galanin in behavioural hyperalgesia in the rat. PLoS One, 9(11):e113077 (2014).

Amorim D, Viisanen H, Wei H, Almeida A, Pertovaara A, Pinto-Ribeiro F. Galanin-Mediated Behavioural Hyperalgesia from the Dorsomedial Nucleus of the Hypothalamus Involves Two Independent Descending Pronociceptive Pathways. PLoS ONE, 10(11):e0142919 (2015).

David-Pereira A, Puga S, Gonçalves SV, Amorim D, Silva C, Pertovaara A, Almeida A, Pinto-Ribeiro F. Metabotropic glutamate 5 receptor in the infralimbic cortex contributes to descending pain facilitation in healthy and arthritic animals. Neuroscience, 312:108-119 (2016).

Amorim D, David-Pereira A, Pertovaara A, Almeida A, Pinto-Ribeiro F. Amitriptyline reverses hyperalgesia and improves associated mood-like disorders in a model of experimental monoarthritis. Behav Brain Res, 265:12-21 (2014).

Silva M, Amorim D, Almeida A, Tavares I, Pinto-Ribeiro F*, Morgado C*. Pronociceptive changes in the activity of rostroventromedial medulla (RVM) pain modulatory cells in the streptozotocin-diabetic rat. Brain Res Bull, 96:39-44 (2013).

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