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Research & Scientists | Neurosciences | People | FABIOTEIXEIRA

 

Name: Fábio Teixeira

Office: G2.25

School Phone: +351 253 604 929

Email: fabioteixeira@med.uminho.pt

 

 

 

Keywords: Regenerative Medicine - Mesenchymal Stem Cells - Stem Cells Secretome - Bioreactor Cell Culture - Stem Cells Isolation - Neurospheres Cell Culture - Animal Experimentation

About

Fábio Teixeira PhD, is a biologist that performed his PhD in Health Sciences at the Life and Health Sciences Research Institute (ICVS), School of Medicine and ICVS/3B’s PT Government Associate Laboratory Braga/Guimarães,University of Minho. His PhD project consisted in the development of new strategies through the use of Mesenchymal Stem Cells (MSCs) and their Secretome as a new possible therapeutic strategy for the regeneration of central nervous system (CNS), in collaboration with the Pharmaceutical Production Research Facility (PPRF), University of Calgary, Canada. During his work, he held the protocol of introduction to the use of Animal House Facilities, where he acquired all the guidelines in the manipulation of the animals (i.e. handling, animal behaviour and surgical processes). In order to complement these skills, he attended to the course of Laboratory Animal Science (LAS), which was successfully completed. In addition, he also has acquired expertise in several areas/techniques: cell culture, establishment of primary cell cultures, proteomic-based analysis, animal stereotaxic surgery, immunocytochemistry/immunohistochemistry, fluorescence and confocal microscopy, molecular analysis (qRT-PCR) and animal behavioral analysis. During his stage at the PPRF, he has also acquired expertise in biotechnological cell culture procedures through the use of bioreactors.

Currently, he is a Junior Principal Investigator at the Life and Health Sciences Research Institute (ICVS) – University of Minho, in which his project consists in the exploration of combinatorial approaches using MSCs secretome and pharmacological strategies for the treatment of Parkinson’s Disease (PD). At the same time, he has also been involved in the design and development of clinical studies, namely in the 1) derivation of inducible pluripotent stem cells (iPSCs) from PD patients, 2) exploring for (new) potential biomarkers for PD both in animal models and human patients, and in the 3) exploration of the effects of a new PD drugs on gait and functional brain network of PD patients.

As a result of his research work, he is currently an author of 22 scientific publications (over than 400 citations; h-index=11), 2 book chapters and more than 20 communications in national and international conferences (oral/poster presentations).

Projects

Exploring the Therapeutic Potential of the Secretome of Mesenchymal Stem Cells in CNS Regenerative Medicine  

Selected Publications

Teixeira FG, Carvalho MM, Sousa N, Salgado AJ. Mesenchymal Stem Cells Secretome: a new paradigm for Central Nervous System Regeneration? Cell Mol Life Sci. 2013 Oct;70(20):3871-82. doi: 10.1007/s00018-013-1290-8. Epub 2013 Mar 1.

Salgado AJ, Sousa JC, Costa BM, Pires AO, Mateus Pinheiro A, Teixeira FG, Pinto L, Sousa N. Mesenchymal Stem Cells Secretome as a Modulator of the Neurogenic Niche: Basic Insights and Therapeutic Opportunities. Front Cell Neurosci, 9:249 (2015).

Salgado AJ, Sousa JC, Costa BM, Pires AO, Mateus Pinheiro A, Teixeira FG, Pinto L, Sousa N. Mesenchymal Stem Cells Secretome as a Modulator of the Neurogenic Niche: Basic Insights and Therapeutic Opportunities. Front Cell Neurosci, 9:249 (2015).

Teixeira FG*, Panchalingam KM*, Anjo Si, Manadas B, Pereira R, Sousa N, Salgado AJ**, Behie LA**. Do Hypoxia/Normoxia Culturing Conditions Change the Neuroregulatory Profile of Wharton Jelly Mesenchymal Stem Cells Secretome?. Stem Cell Res Ther, 6(1):133 (2015).

Carvalho MM, Teixeira FG, Reis RL, Sousa N, Salgado AJ. Mesenchymal stem cells in the umbilical cord: phenotypic characterization, secretome and applications in central nervous system regenerative medicine. Curr Stem Cell Res Ther. 2011 Sep;6(3):221-8.

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