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Research & Scientists | Neurosciences | People | IOANNIS

 

Name: Ioannis Sotiropoulos

Office: G2.16

School Phone: +351 253 604 924

Email: ioannis@med.uminho.pt

 

 

 

Keywords: stress Alzheimer´s disease neurodegeneration depression Tau Amyloid

About

Ioannis (John) Sotiropoulos is a young P.I. joined the “Aging and Dementia” research line at Neuroscience Research Domain which is coordinated by Professor Nuno Sousa, co-Director of School of Health and Life Sciences at University of Minho.

Matching with the team research interests on stress role on brain function under normal and pathological conditions, his main research work in cellular and animal models targets towards the mechanistic understanding of stress and glucocorticoids (GC) actions on neuronal plasticity and function in association with stress-related pathologies characterized by neuronal atrophy and dysfunction as well as cognitive and emotional deficits. In addition, his studies focuses on the detailed investigation of role of chronic stress on pathogenic pathways found in neurodegenerative disorders such as Alzheimer’s disease and their connection to another stress-related disorder, depression, towards the exploration of novel potential biological targets for preventative and curative intervention of these diseases. Applying various experimental approaches and technical tools including molecular, cellular, morpho- and ultrastructural, electrophysiological and behavioral analysis, John´s and colleagues work highlights novel molecules mediating the effects of stress on the neural substrates that regulate depressive- and anxiety-like behavior providing hints about the novel cellular mechanisms that may link stress with brain pathology.

Projects

Cumulative stress: the link between depression and dementia (Leader) 

Environmental stress and Alzheimer´s disease pathologies (Leader) 

Sensomotor mechanisms and Alzheimer´s disease pathology (Leader) 

Deciphering the role of Aß and TAU among neuronal subpopulations in Alzheimer´s disease network malfunction.  

Selected Publications

Lopes S, Vaz-Silva J, Pinto V, Dalla C, Kokras N, Bedenk B, Mack N, Czisch M, Almeida OFX, Sousa N, Sotiropoulos I. Tau protein is essential for stress-induced brain pathology. PNAS USA, 113(26):E3755-E3763 (2016)

Lopes S, Teplytska L, Vaz-Silva J, Dioli C, Trindade R, Morais M, Webhofer C, Almeida OFX, Turck C, Sousa N, Sotiropoulos I, Filiou MD. Tau deletion prevents stress-induced dendritic atrophy in prefrontal cortex: role of synaptic mitochondria. Cereb Cortex 2017 Apr 1;27(4):2580-2591.

Sotiropoulos I, Catania C, Pinto LG, Silva R, Pollerberg GE, Takashima A, Sousa N, Almeida OF. Stress acts cumulatively to precipitate Alzheimer's disease-like tau pathology and cognitive deficits. J Neurosci. 2011 May 25;31(21):7840-7. doi: 10.1523/JNEUROSCI.0730-11.2011.

Lopes S, Lopes A, Pinto V, Guimarães MR, Sardinha VM, Duarte-Silva S, Pinheiro S, Pizarro J, Oliveira JF, Sousa N, Leite-Almeida H, Sotiropoulos I. Absence of Tau triggers age-dependent sciatic nerve morphofunctional deficits and motor impairment. Aging Cell, 15(2):208-216 (2016)

Kimura T, Whitcomb D, Jo J, Regan P, Piers T, Heo S, Brown C, Seok H, Sotiropoulos I, Kim E, Collingridge G, Takashima A, Kei C. Microtubule associated protein tau (MAPT) is essential for long-term depression in the hippocampus. Philos Trans R Soc Lond B Biol Sci. 2013 Dec 2;369(1633):20130144. doi: 10.1098/rstb.2013.0144. Print 2014 Jan 5

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