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Research & Scientists | People | EGIDIOTORRADO

 

Name: Egídio Torrado

Office: I3.11

School Phone: +351 604 907

Email: egidiotorrado@med.uminho.pt

 

 

 

Keywords: Tuberculosis CD4 T cells Effector T cells Memory T cells IL-12 family of cytokines

About

The protective immune response to Mycobacterium tuberculosis requires tight regulation in order to prevent the development of pathological consequences to the host. My research is focused on understanding the mechanisms that regulate this response both during the innate and chronic phases of the infection. With particular emphasis in the IL-12 family ofcytokines, I am interested in the impact of IL-23 in the innate immune responseto M. tuberculosis and how innate cells that respond to this cytokine bridge innate and acquired immunity to M. tuberculosis. Further, I am interested in understanding how IL-12 and IL-27 impact the T cell response during the chronic phase of the infection specificaly, in the maintenance of the T cell response and the development of pathologicalconsequences to the host.  

 

Projects

Modulating bacteriostasis in M. tuberculosis infection: impact of the microbiome (Leader) 

Understanding BCG vaccination: Correlates of protection/pathology following infection with M. tuberculosis (Leader) 

Dynamics of granuloma assembling  

Evaluation of immune-determinants associated with resistance/susceptibility to Paracoccidioides brasiliensis: a mouse model perspective  

Innate immunity & Inflammation: impact on the immune response to intracellular pathogens: (M. tuberculosis; Listeria; Klebsiella)  

Lung development orchestration by tissue macrophages  

Pathogen Diversity and Epitope-based Immunoinformatics in Tuberculosis  

Selected Publications

Moreira-Teixeira L, Sousa J, McNab FW, Torrado E, Cardoso F, Machado H, Castro F, Cardoso V, Gaifem J, Wu X, Appelberg R, Castro AG, O'Garra A, Saraiva M. Type I IFN Inhibits Alternative Macrophage Activation during Mycobacterium tuberculosis Infection and Leads to Enhanced Protection in the Absence of IFN-gamma Signaling. J Immunol. 2016 Dec 15;197(12):4714-4726.

Torrado E, Fraga AG, Logarinho E, Martins TG, Carmona JA, Gama JB, Carvalho MA, Proença F, Castro AG, Pedrosa J. IFN-gamma-dependent activation of macrophages during experimental infections by Mycobacterium ulcerans is impaired by the toxin mycolactone. J Immunol. 2010 Jan 15;184(2):947-55. doi: 10.4049/jimmunol.0902717. Epub 2009 Dec 11.

Gonçalves C, Torrado E, Martins T, Pereira P, Pedrosa J, Gama M. Dextrin nanoparticles: studies on the interaction with murine macrophages and blood clearance. Colloids Surf B Biointerfaces. 2010 Feb 1;75(2):483-9. doi: 10.1016/j.colsurfb.2009.09.024. Epub 2009 Sep 25.

Cruz A, Ludovico P, Torrado E, Gama JB, Sousa J, Gaifem J, Appelberg R, Rodrigues F, Cooper AM, Pedrosa J, Saraiva M, Castro AG. "IL-17A promotes intracellular growth of Mycobacterium by inhibiting apoptosis of infected macrophages". Front. Immunol. 6:498.

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