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Research & Scientists | People | FILIPARIBEIRO

 

Name: Filipa Pinto-Ribeiro

Office: G2.27

School Phone: +351 253 604 852

Email: filiparibeiro@med.uminho.pt

 

 

 

Keywords: Pain Osteoarthritis Diabetes Descending Pain Facilitation Animal Models of Nociception Pain and Cognitive/Mood Disorders Comorbidities Behaviour Electrophysiology Glutamatergic transmission Antidepressants

About

Filipa Pinto-Ribeiro (MA, MSc, PhD) is an Assistant Professor at the School of Health Sciences at the University of Minho. Academically, she teaches Histology and Embryology as part of the Organic and Functional Systems Course and she coordinates the Option Projects of medical students. At the moment FPR supervises a PhD Student and two Master Students.

She is a neuroscientist with a background in Marine Biology and Endocrinology. Presently, she is part of the group dedicated to research pain under the leadership of Professor Armando Almeida with whom she co-oversees a privately funded project involving the screening of new drugs for the management of chronic pain and a FCT funded project involving the evaluation of the impact of heavy metals on fish brain morphology.

During her PhD, FPR moved to Finland in order to characterize electrophysiologically the effects of the manipulation of the paraventricular nucleus of the hypothalamus (PVN) upon descending pain modulation by the rostral ventromedial medulla (RVM) and the caudal ventrolateral medulla (CVLM) with Professor Antti Pertovaara (Department of Physiology) at the Biomedicum Institute - Helsinki University.

Her main research interests are focused on the comorbidity between chronic pain and cognitive/mood disorders and its impact on pain facilitation. Her approaches include the use of experimental models of monoarthritis, osteoarthritis andtype-1 diabetes, single cell electrophysiological recordings, pharmacological manipulations to differentially activate/inhibit different pain modulatory circuits, the stereological analysis of volumes and number of cells, immunohistochemistry and a broad spectrum of behavioural tasks to evaluate nociceptive, cognitive and emotional performance.

FPR has published 13 peer-reviewed research articles in international Journals and serves as an Ad hoc reviewer for several neuroscience journals. She is a member of the Sociedade Portuguesa de Neurociências and the International Society for the Study of Pain (IASP).


Collaborators:

Diana Amorim - Post-hoc - Involvement of the hypothalamus and galanin in pain-depression comorbidity and pain facilitation/Characterization of mood comorbidities in an animal model of diabetes.

Ana David-Pereira - PhD Student - Role of metabotropic glutamate receptors in pain facilitation from the medial PreFrontal Cortex

Sónia Puga - Researcher - Impact of heavy metals on fish brain morphology.

Sara Gonçalves - MSc Student - Changes in supraspinal mGluR expression in monoarthritis.

Projects

Impact of neurotoxicity on fish central nervous system (Leader) 

Pain modulation in chronic pain syndromes and comorbid mood disorders (Leader) 

Selected Publications

Amorim D, Viisanen H, Wei H, Almeida A, Pertovaara A, Pinto-Ribeiro F. Galanin-Mediated Behavioural Hyperalgesia from the Dorsomedial Nucleus of the Hypothalamus Involves Two Independent Descending Pronociceptive Pathways. PLoS ONE, 10(11):e0142919 (2015).

9. David-Pereira A, Sagalajev B, Wei H, Almeida A, Pertovaara A, Pinto-Ribeiro F. The medullary dorsal reticular nucleus as a relay for descending pronociception induced by the mGluR5 in the rat infralimbic cortex. Neuroscience, 349:341-354 (2017).

Amorim D*, Puga S*, Bragança R, Braga A, Pertovaara A, Almeida A, Pinto-Ribeiro F. Minocycline reduces mechanical allodynia and depressive-like behaviour in type-1 diabetes mellitus in the rat. Behav Brain Res, 327:1-10 (2017)

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