Filipa Pinto-Ribeiro (MA, MSc, PhD) is an Assistant Professor at the School of Health Sciences at the University of Minho. Academically, she teaches Histology and Embryology as part of the Organic and Functional Systems Course and she coordinates the Option Projects of medical students. At the moment FPR supervises a PhD Student and two Master Students.
She is a neuroscientist with a background in Marine Biology and Endocrinology. Presently, she is part of the group dedicated to research pain under the leadership of Professor Armando Almeida with whom she co-oversees a privately funded project involving the screening of new drugs for the management of chronic pain and a FCT funded project involving the evaluation of the impact of heavy metals on fish brain morphology.
During her PhD, FPR moved to Finland in order to characterize electrophysiologically the effects of the manipulation of the paraventricular nucleus of the hypothalamus (PVN) upon descending pain modulation by the rostral ventromedial medulla (RVM) and the caudal ventrolateral medulla (CVLM) with Professor Antti Pertovaara (Department of Physiology) at the Biomedicum Institute - Helsinki University.
Her main research interests are focused on the comorbidity between chronic pain and cognitive/mood disorders and its impact on pain facilitation. Her approaches include the use of experimental models of monoarthritis, osteoarthritis andtype-1 diabetes, single cell electrophysiological recordings, pharmacological manipulations to differentially activate/inhibit different pain modulatory circuits, the stereological analysis of volumes and number of cells, immunohistochemistry and a broad spectrum of behavioural tasks to evaluate nociceptive, cognitive and emotional performance.
FPR has published 13 peer-reviewed research articles in international Journals and serves as an Ad hoc reviewer for several neuroscience journals. She is a member of the Sociedade Portuguesa de Neurociências and the International Society for the Study of Pain (IASP).
Diana Amorim - Post-hoc - Involvement of the hypothalamus and galanin in pain-depression comorbidity and pain facilitation/Characterization of mood comorbidities in an animal model of diabetes.
Ana David-Pereira - PhD Student - Role of metabotropic glutamate receptors in pain facilitation from the medial PreFrontal Cortex
Sónia Puga - Researcher - Impact of heavy metals on fish brain morphology.
Sara Gonçalves - MSc Student - Changes in supraspinal mGluR expression in monoarthritis.
Amorim D, David-Pereira A, Marques P, Puga S, Rebelo P, Costa P, Pertovaara A, Almeida A, Pinto-Ribeiro F. A role of supraspinal galanin in behavioural hyperalgesia in the rat. PLoS One, 9(11):e113077 (2014).
Gonçalves L, Silva R, Pinto-Ribeiro F, Pêgo JM, Bessa JM, Pertovaara A, Sousa N, Almeida A. Neuropathic pain is associated with depressive behaviour and induces neuroplasticity in the amygdala of the rat. Exp Neurol. 2008 Sep;213(1):48-56. doi: 10.1016/j.expneurol.2008.04.043. Epub 2008 May 20.
Amorim D, David-Pereira A, Pertovaara A, Almeida A, Pinto-Ribeiro F. Amitriptyline reverses hyperalgesia and improves associated mood-like disorders in a model of experimental monoarthritis. Behav Brain Res, 265:12-21 (2014).
Pinto-Ribeiro F*, Amorim D*, David-Pereira A, Monteiro AM, Costa P, Pertovaara A, Almeida A. Pronociception from the dorsomedial nucleus of the hypothalamus is mediated by the rostral ventromedial medulla in healthy controls but is absent in arthritic animals. Brain Res Bull, 99C:100-108 (2013)
Silva M, Amorim D, Almeida A, Tavares I, Pinto-Ribeiro F*, Morgado C*. Pronociceptive changes in the activity of rostroventromedial medulla (RVM) pain modulatory cells in the streptozotocin-diabetic rat. Brain Res Bull, 96:39-44 (2013).