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Name: João Carlos Sousa

Office: G2.22

School Phone: +351 253 604 848

Email:

 

 

 

Keywords: modulation of neural cells subventricular zone choroid plexus development neural cells extracellular matrix

About

João Carlos Sousa (PhD) is an Assistant Professor in the medical school, School of HealthSciences, University of Minho, Braga, Portugal.

He is a neuroscientist who did his PhD in neuroendocrinology of thyroid hormones, namely how a carrier protein of thyroid hormones (transthyretin) influences behavior. He then did his post-doctoral training in the neurobiology of stress and later in the role of the epithelial cells of the choroid plexus in the modulation of cerebrospinal fluid content.

He currently is interested in understanding how the external millieu modulates neural progenitor cells proliferation and differentiation by using the subventricular zone, the cerebrospinal fluid and choroid plexus as an interface model between the periphery and the central nervous system. He also is interested in understanding how the extracellular matrix influences cell-cell communication in neural cells during development.

He haspublished 24 articles in peer-reviewed journals.
He has reviewed for international journals (Neuroscience, PLoSOne, FEBS Journal, Frontiers in Neuroscience).



Projects

Neural cells modulation and support (Leader) 

Communication across the barriers  

Multiple Sclerosis: Studying lipocalin 2 as a novel player in the pathophysiology of the disease  

MyHealth  

Selected Publications

Dias-Ferreira E, Sousa JC, Melo I, Morgado P, Mesquita AR, Cerqueira JJ, Costa RM, Sousa N. Chronic stress causes frontostriatal reorganization and affects decision-making. Science. 2009 Jul 31;325(5940):621-5. doi: 10.1126/science.1171203.

Ferreira AC, Mesquita SD, Sousa JC, Correia-Neves M, Sousa N, Palha JA, Marques F. From the periphery to the brain: lipocalin-2, a friend or foe? Prog Neurobiol, 131:120-136 (2015).

Mesquita SD, Ferreira AC, Sousa JC, Correia-Neves M, Sousa N, Marques F. "Insights on the pathophysiology of Alzheimer's disease: the crosstalk between amyloid pathology, neuroinflammation and the peripheral immune system". Neurosci Biobehav Rev. 2016 Jun 18;68:547-562.

Dá Mesquita S, Ferreira AC, Sousa JC, Correia-Neves M, Sousa N, Marques F. Insights on the pathophysiology of Alzheimer's disease: The crosstalk between amyloid pathology, neuroinflammation and the peripheral immune system. Neurosci Biobehav Rev, 68:547-562 (2016)

Mesquita SD, Ferreira AC, Falcão AM, Sousa JC, Oliveira TG, Correia-Neves M, Sousa N, Marques F, Palha JA. Lipocalin 2 modulates the cellular response to amyloid beta. Cell Death Differ. 2014 May 23. doi: 10.1038/cdd.2014.68. [Epub ahead of print]

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