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Research & Scientists | People | NOSORIO

 

Name: Nuno S. Osório

Office: I3.09

School Phone: +351 253 604 904

Email: nosorio@med.uminho.pt

 

 

 

Keywords: Diversifying Selection TB Tuberculosis MTBC Genetic Diversity Pathogen Evolution Host-pathogen interaction Drug Resistance

About

Nuno S. Osório is an Assistant Investigator and Professor at the Life and Health Sciences Research Institute (ICVS), ICVS/3B’s - PT Government Associate Laboratory and the School of Health Sciences, University of Minho.

His research interest is the diversity and evolution o fmicroorganisms and virus and the understanding at the molecular level of the structural and functional impact on host/pathogen interaction and human disease.

Presently, he is mainly focused on genome-driven studies of Tuberculosis (TB). TB is the infectious disease with the second highest mortality burden in the world. With the rapidly growing understanding of the evolution, population structure and extent of genetic diversity amongst clinical isolates of TB-causing bacteria - members of the Mycobacterium tuberculosis complex (MTBC)- his main goal is to perform integrated genome-driven studies to identify genetic markers in the pathogen underlying the diversity of clinical outcomes and to contribute for the development of effective therapeutic strategies to stop TB.

Projects

Computational Molecular Biology and Evolution of the Mycobacterium tuberculosis Complex (Leader) 

Pathogen Diversity and Epitope-based Immunoinformatics in Tuberculosis (Leader) 

Functional impact of allelic variants of metabolic genes under positive selection in the fitness of Mycobacterium tuberculosis  

Importance of Plasmodium falciparum ABC transporters in antimalarial drug resistance  

Selected Publications

Osório, Nuno S., Fernando Rodrigues, Sebastien Gagneux, Jorge Pedrosa, Marta Pinto-Carbó, António G. Castro, Douglas Young, Iñaki Comas, and Margarida Saraiva. "Evidence for diversifying selection in a set of Mycobacterium tuberculosis genes in response to antibiotic and non-antibiotic related pressure." Molecular Biology and Evolution (2013) 30 (6): 1326-1336. doi: 10.1093/molbev/mst038

Carvalho A, Osório NS, Saraiva M, Cunha C, Almeida AJ, Teixeira-Coelho M, Ludovico P, Pedrosa J, Pitzurra L, Aversa F, Romani L, Castro AG, Rodrigues F. The C allele of rs5743836 polymorphism in the human TLR9 promoter links IL-6 and TLR9 up-regulation and confers increased B-cell proliferation. PLoS One. 2011;6(11):e28256. doi: 10.1371/journal.pone.0028256. Epub 2011 Nov 23.

Carvalho A, Costa P, Triunfante V, Branca F, Rodrigues F, Santos CL, Correia-Neves M, Saraiva M, Lecour H, Castro AG, Pedrosa J, Osório NS. Analysis of a Local HIV-1 Epidemic in Portugal Highlights Established Transmission of non-B and -G Subtypes. J Clin Microbiol. 2015 Feb 18. pii: JCM.03611-14.

Carmona J, Cruz A, Moreira-Teixeira L, Sousa C, Sousa J, Osorio NO, Saraiva AL, Svenson S, Kallenius G, Pedrosa J, Rodrigues F, Castro AG, Saraiva M. (2013) Mycobacterium tuberculosis Strains Are Differentially Recognized by TLRs with na Impact on the Immune Response. PLoS ONE 8(6): e67277. doi:10.1371/journal.pone.0067277

Veiga MI, Osório NS, Ferreira PE, Franzén O, Dahlstrom S, Lum JK, Nosten F, Gil JP. Complex polymorphisms in the Plasmodium falciparum Multidrug Resistance Protein 2 gene and its contribution to antimalarial response. Antimicrob Agents Chemother. 2014 Sep 29. pii: AAC.03337-14. [Epub ahead of print]

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