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Research & Scientists | People | OLGAMARTINHO

 

Name: Olga Martinho

Office: GI.28/I1.02

School Phone: +351 253 604 837/68

Email: olgamartinho@med.uminho.pt

 

 

 

Keywords: Cancer Oncobiology Molecular Targeted Therapies

About

Degree in Applied Biology from University of Minho, Portugal (2006). PhD in Health Sciences from the University of Minho, Portugal (2011). Developed her PhD thesis at the ICVS in the oncobiology field. She did a year (2012) of postdoctoral research in the Molecular Oncology Research Center, Barretos, Brazil where is currently a collaborating investigator. She was Professor of the Faculty of Health Sciences Dr. Paulo Prata Barretos, Brazil in 2012 and is currently professor of the post-graduation program in oncology of the PIOXII Foundation - Barretos Cancer Hospital, Brazil. Since 2013 she is postdoctoral fellowship in the oncobiology field at the ICVS.

The main research interests are: molecular and cellular biology of solid tumors; molecular targeted therapies in oncology; receptor tyrosine kinases (RTKs) - biologic functions, signaling, and potential therapeutic targeting in solid tumors.

Projects

Molecularly targeted therapies: mechanisms of resistance (Leader) 

Receptor tyrosine kinases (RTKs): signaling, biologic functions, and potential therapeutic targeting in solid tumors  

Selected Publications

Moniz S, Martinho O, Pinto F, Sousa B, Loureiro C, Oliveira MJ, Moita LF, Honavar M, Pinheiro C, Pires M, Lopes JM, Jones C, Costello JF, Paredes J, Reis RM, Jordan P. Loss of WNK2 expression by promoter gene methylation occurs in adult gliomas and triggers Rac1-mediated tumour cell invasiveness. Hum Mol Genet, 2013;22(1):84-95.

Costa AM, Pinto F, Martinho O, Oliveira MJ, Jordan P, Reis RM. Silencing of the tumor suppressor gene WNK2 is associated with upregulation of MMP2 and JNK in gliomas. Oncotarget, December 22, 2014.

Miranda-Gonçalves V, Granja S, Martinho O, Honavar M, Pojo M, Costa BM, Pires MM, Pinheiro C, Cordeiro M, Bebiano G, Costa P, Reis RM, Baltazar F. Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenotype of glioblastomas. Oncotarget, 2016; 7(29):46335-46353

Miranda-Gonçalves V, Honavar M, Pinheiro C, Martinho O, Cordeiro M, Bebiano G, Costa P, Reis RM, Baltazar F. Monocarboxylate transporters (MCTs) in gliomas: Expression and exploitation as therapeutic target. Neuro-Oncology, 2013;15(2):172-88.

Martinho O, Longatto-Filho A, Lambros MB, Martins A, Pinheiro C, Silva A, Pardal F, Amorim J, Mackay A, Milanezi F, Tamber N, Fenwick K, Ashworth A, Reis-Filho JS, Lopes JM, Reis RM. Expression, mutation and copy number analysis of platelet-derived growth factor receptor A (PDGFRA) and its ligand PDGFA in gliomas. Br J Cancer. 2009 Sep 15;101(6):973-82. doi: 10.1038/sj.bjc.6605225. Epub 2009 Aug 25.

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