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Research & Scientists | People | TIAGOLIVEIRA

 

Name: Tiago Gil Oliveira

Office: G2.15

School Phone: +351 253 604 923

Email: tiago@med.uminho.pt

 

 

 

Keywords: lipids phospholipids hippocampus Alzheimer's disease chronic stress phospholipase D

About

Tiago Gil Oliveira (MD/PhD) is an Assistant Professor at the School of Medicine, University of Minho. 

He is part of the faculty (Anatomy) of the Medical Degree at University of Minho. 
 
Currently, he is also a Neuroradiologist at "Hospital de Braga".

He is a member of the Neuroscience Research Domain at ICVS/University of Minho. 

His research main interests are focused in understanding the role of signaling lipids in brain function and dysfunction. 

High school
1999-2002
Francisco de Holanda High School, Guimarães, Portugal.

University – Medical School
2002-2011
MD/PhD programme
School of Health Sciences, University of Minho, Braga, Portugal.

University – PhD
2007-2010
Columbia University – New York, USA – under the supervision of Gilbert Di Paolo.
Co-supervisor: Nuno Sousa (Minho University, Braga, Portugal).
"The role of phospholipase D in Alzheimer's disease"


SELECTED SCIENTIFIC PUBLICATIONS

Phospholipase D functional ablation has a protective effect in an Alzheimer’s disease Caenorhabditis elegans model. Bravo FV, Da Silva JD, Chan RB, Di Paolo G, Teixeira-Castro A, Oliveira TG. Sci Rep. 2018 Feb 23; 8 (1):3540.

Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures. Miranda AM, Lasiecka ZM, Xu Y, Neufeld J, Shahriar S, Simoes S, Chan RB, Oliveira TG, Small SA, Di Paolo G. Nat Commun. 2018 Jan 18;9(1):291.

Lipids under stress--a lipidomic approach for the study of mood disorders. Miranda AM, Oliveira TG. Bioessays. 2015 Nov;37(11):1226-35. Epub 2015 Oct 1.

The impact of chronic stress on the rat brain lipidome. Oliveira TG, Chan RB, Bravo FV, Miranda A, Silva RR, Zhou B, Marques F, Pinto V, Cerqueira JJ, Di Paolo G, Sousa N. Mol Psychiatry. 2016 Jan;21(1):80-8. Epub 2015 Mar 10.

Differential impact of chronic stress along the hippocampal dorsal-ventral axis. Pinto V, Costa JC, Morgado P, Mota C, Miranda A, Bravo FV, Oliveira TG, Cerqueira JJ, Sousa N. Brain Struct Funct. 2015 Mar;220(2):1205-12.

Comparative lipidomic analysis of mouse and human brain with Alzheimer disease. Chan RB, Oliveira TG, Cortes EP, Honig LS, Duff KE, Small SA, Wenk MR, Shui G, Di Paolo G. J Biol Chem. 2012 Jan 20;287(4):2678-88.

Phospholipase D2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits. Oliveira TG, Chan RB, Tian H, Laredo M, Shui G, Staniszewski A, Zhang H, Wang L, Kim TW, Duff KE, Wenk MR, Arancio O, Di Paolo G. J Neurosci. 2010 Dec 8;30(49):16419-28.

Phospholipase D in brain function and Alzheimer's disease. Oliveira TG, Di Paolo G. Biochim Biophys Acta. 2010 Aug;1801(8):799-805. Epub 2010 Apr 23. Review.



PATENTS
“Modulation of Phospholipase D for the treatment of neurodegenerative disorders”
Gilbert Di Paolo, Tiago Gil Oliveira, Tae-Wan Kim.
WIPO Patent WO/2010/138869A1

“Modulation of Phospholipase D for the treatment of the acute and chronic effects of ethanol” Gilbert Di Paolo, Tiago Gil Oliveira, Markus Wenk, Samuel G. Frere, Robin B. Chan.
WIPO Patent WO/2011/014622A1



FUNDING
2012-2015 – Fundação para a ciência e tecnologia
“The role of brain lipid metabolism in the modulation of chronic stress effects”
€155.373 - PTDC/SAU-NMC/118971/2010

2014 - Clinic Academic Center - Braga
"Antiphospholipid syndrome: identification of new biomarkers"
€10.000

2015-2017 - BIAL Foundation
"The impact of lipid signaling modulation in cognition"
€50.000 - 253/14












Selected Publications

Oliveira TG, Chan RB, Bravo FV, Miranda A, Silva RR, Zhou B, Marques F, Pinto V, Cerqueira JJ, Di Paolo G, Sousa N. The impact of chronic stress on the rat brain lipidome. Mol Psych, 21(1):80-88 (2016).

Mesquita SD, Ferreira AC, Falcão AM, Sousa JC, Oliveira TG, Correia-Neves M, Sousa N, Marques F, Palha JA. Lipocalin 2 modulates the cellular response to amyloid beta. Cell Death Differ. 2014 May 23. doi: 10.1038/cdd.2014.68. [Epub ahead of print]

Pinto V, Costa JC, Morgado P, Mota C, Miranda A, Bravo FV, Oliveira TG, Cerqueira JJ, Sousa N. Differential impact of chronic stress along the hippocampal dorsal-ventral axis. Brain Struct Funct, in press

Oliveira TG, Chan RB, Tian H, Laredo M, Shui G, Staniszewski A, Zhang H, Wang L, Kim TW, Duff KE, Wenk MR, Arancio O, Di Paolo G. Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits. J Neurosci. 2010 Dec 8;30(49):16419-28. doi: 10.1523/JNEUROSCI.3317-10.2010.

Chan RB1, Oliveira TG, Cortes EP, Honig LS, Duff KE, Small SA, Wenk MR, Shui G, Di Paolo G. Comparative lipidomic analysis of mouse and human brain with Alzheimer disease. J Biol Chem. 2012 Jan 20;287(4):2678-88. doi: 10.1074/jbc.M111.274142. Epub 2011 Dec 1.

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