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Research & Scientists | Surgical Sciences | People | FBALTAZAR

 

Name: Fátima Baltazar

Office: G1.24

School Phone: +351 253 604 828

Email: fbaltazar@med.uminho.pt

 

 

 

Keywords: monocarboxylate transporters cancer metabolism cancer targeted therapy

About

Fátima Baltazar (Baltazar F) holds a degree in Pharmaceutical Sciences (1992), Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal. 

From 1994-1998, she did a PhD in Biological Sciences at The University of Hull, Hull, UK. From 1998 to 2003, she was a Post-doc fellow at the Biology Department, University of Minho. From 2003 to 2014, she was Assistant Professor and from 2014 to present she is Associate Professor at the Medical School of the University of Minho, Braga, Portugal.

She started her research on the Oncobiology field in 2005 and she is currently a group leader and senior PI at ICVS (Life and Health Sciences Research Institute).


In the last years, Fatima’s main research interest has been on cancer metabolism, especially on the role of monocarboxylate transporters (MCTs), using human tumor samples and suitable models for in vitro and in vivo studies. 


Fátima Baltazar has published 97 international peer-reviewed research articles, 2 national research articles and 8 book chapters.


She supervised 5 post-doc projects, 8 PhD thesis, 16 Master thesis and several under-graduated research projects and is presently supervising 4 post-doc projects, 6 PhD thesis and 3 Master thesis.

Projects

Development of 3D culture systems for in vitro study of tumour pathophysiology (Leader) 

Role of Monocarboxylate transporters (MCTs) in cancer (Leader) 

Molecularly targeted therapies: mechanisms of resistance  

Selected Publications

Miranda-Gonçalves V, Granja S, Martinho O, Honavar M, Pojo M, Costa BM, Pires MM, Pinheiro C, Cordeiro M, Bebiano G, Costa P, Reis RM, Baltazar F. Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenotype of glioblastomas. Oncotarget, 2016; 7(29):46335-46353

Miranda-Gonçalves V, Honavar M, Pinheiro C, Martinho O, Cordeiro M, Bebiano G, Costa P, Reis RM, Baltazar F. Monocarboxylate transporters (MCTs) in gliomas: Expression and exploitation as therapeutic target. Neuro-Oncology, 2013;15(2):172-88.

Pértega-Gomes N, Felisbino S, Massie C, Vizcaíno JR, Coelho R, Sandi C, Sousa S, Jurmeister S, Ramos-Montoya A, Asim M, Tran M, Oliveira E, Lobo da Cunha A, Maximo V, Baltazar F, Neal DE, Fryer L. A glycolytic phenotype is associated with prostate cancer progression and aggressiveness: A role for Monocarboxylate Transporters as metabolic targets for therapy. J Pathol, 2015; 236(4):517-530

Morais-Santos F, Granja S, Miranda-Gonçalves V, Moreira A, Queirós S, Vilaça JL, Schmitt FC, Longatto-Filho A, Paredes J, Baltazar F, Pinheiro C. Targeting lactate transport suppresses in vivo breast tumour growth. Oncotarget, 2015; 6(22): 19177-19189.

Granja S, Marchiq I, Le Floch E, Souto-Moura C, Baltazar F, Pouyssegur J. Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status. Oncotarget, 2014; ahead of print.

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