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Science & Society | News | Researchers from ICVS get further insight on the impact of prenatal stress in the developing brain

Researchers from ICVS get further insight on the impact of prenatal stress in the developing brain


Stress perception, response, adaptation, and coping strategies are individually distinct, and the sequel of stress and/or glucocorticoids is also distinct between subjects. Researchers from ICVS have discovered that early life exposure to glucocorticoids program the cholinergic circuit, leading to increased hyper-reactivity to negative stimuli. This programming effect seemed to be restricted to the mesopontine circuitry, hinting that this pathway may be important in setting individual stress vulnerability threshold.

Original article:
Glucocorticoid programming of the mesopontine cholinergic system
Sónia Borges, Bárbara Coimbra, Carina Soares-Cunha, Ana Paula Ventura-Silva, Luisa Pinto, Miguel M Carvalho, José M Pêgo, Ana J Rodrigues* and Nuno Sousa*
doi:10.3389/fendo.2013.00190
http://www.frontiersin.org/Neuroendocrine_Science/10.3389/fendo.2013.00190/abstract


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