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Researchers from ICVS/3Bs develop a new transgenic mouse model of Machado-Joseph disease and demonstrate a delay of the progression of the disease by 17-DMAG treatment

In a recently published work in Neurotherapeutics, a team of researchers at the Life and Health Sciences Research Institute of the University of Minho led by Prof. Patrícia Maciel and including Anabela Silva-Fernandes and Sara Duarte-Silva describe a new mouse model of Machado-Joseph disease, an inherited neurodegenerative disease caused by mutation in the ATXN3 gene, which until now remains untreatable. This transgenic mouse recapitulates several features of the human disease at the clinical an ...

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A delegation from the Shanghai Institute of Materia Medica visits the University of Minho

A delegation of the Shanghai Institute of Materia Medica (SIMM) of the Chinese Academy of Sciences visited University of Minho and the facilities of the ICVS/3B’s Associate Laboratory. The delegation composed by SIMM directors (Cheng Jianjun and Li Jun) and scientists (Zuo Jianping and Tang Wei) had the opportunity to know more about the research that is performed at ICVS/3B’s, to meet with our scientists and discuss future collaborative projects between the Portuguese and Chinese re ...

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ICVS researchers developed a new behavioral test to assess anhedonia

In a work by António Mateus-Pinheiro, Patrícia Patrício and colleagues, recently published in Frontiers in Behavioral Neuroscience, the ICVS researchers developed a new test to evaluate anhedonic behavior in rodents, called Sweet Drive Test (SDT). Anhedonia is the absence of pleasure from a previously rewarding experience or activity and constitutes a cardinal mark of depression. Studying the neurobiological basis of anhedonia in rodent models is therefore highly relevan ...

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ICVS Researchers contribute to the identification of a genetic factor involved in susceptibility to fungal infections in subjects undergoing bone marrow transplantation

An international team, led by Agostinho Carvalho (University of Perugia, Italy and ICVS/3B ' s, University of Minho, Portugal), identified a genetic risk factor associated with reduced levels of pentraxin 3 (PTX3; involved in opsonization of Aspergillus fumigatus fungus), which results in increased susceptibility to aspergillosis in hematologic patients undergoing bone marrow transplantation. This work opens the door to new therapeutic interventions and will make an additional genetic stratifica ...

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ICVS researcher wins the 2013 edition of “Bolsa D.Manuel de Mello”

Helder Novais e Bastos was awarded the “Bolsa D. Manuel de Mello” in the value of 12,500 euros with the project “Impact of Mycobacterium tuberculosis phylogeny in clinical heterogeneity” in a collaboration between the Microbiology and Infection Research domain of ICVS and Hospital de São João, EPE. This prize is awarded annually by the “Amélia de Mello Foundation” in partnership with “José de Mello Saúde” and is intended to ...

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