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ICVS researchers awarded the Janssen Innovation Award (1st edition).

The 1st prize of the JanssenInnovation Award was awarded to an ICVS/School of Medicine Neurosciences team. The team, led by IoannisSotiropoulos, characterized the relationship between chronic stress, depressionand Alzheimer's disease. The work entitled "Tautherapeutics in stress-evoked brain pathology: exploring the path fromdepression to Alzheimer´s disease" showed that chronic stress triggersmechanisms that induced neuronal dysfunction, and that my contribute forAlzheime ...

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Neide Vieira awarded a NARSAD Young Investigator Grant by the Brain & Behavior Research Foundation

The NARSAD Young Investigator Grant provides support for the most promising young scientists conducting neurobiological research. A NARSAD Grant is one of the highest distinctions in the field of mental health research, and is awarded by the scientific council of the Brain & Behavior Research Foundation, which is made up of 165 prestigious volunteers, widely recognized as the leaders in every major area of brain and behavior research. This award will allow Neide Vieira to extend the work ...

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A New Multidisciplinary Strategy for Spinal Cord Injury Regeneration

Main findings of this work The spinal cord can be compared to a highway, allowing information to flow, in the form of nervous impulses, from the brain to rest of the body and vice-versa. When the spinal cord is injured, most of the times as a consequence of an accident, its structural integrity is affected causing the disruption of the nervous connections and impulses within. This has a major impact on SCI patients as it leads to severe motor deficits, as well as other complications. The vast m ...

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New light at the link between depression and Alzheimer’s disease.

Novel studies from ICVS institute shows that chronic stress precipitates depressive pathology through neurotoxic mechanisms of Alzheimer’s disease Main findings: Prolong stressful periods in our life could be causally related to the development of depression, a mental disorder characterized by depressed mood, loss of interest or pleasure low self-worth as well as cognitive deficits that severely damage the individual’s life. More recently, depression is also shown to increase the ...

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An unexpected role for striatal D2 neurons in motivation

Main findings of this work When humans or animals execute actions that satisfy a necessity or desire, they feel pleasure. This perception is important for survival because it makes individuals search and work for things they want/need.  The neuronal circuit involved in reward and motivated behaviors is complex, but one crucial region is the nucleus accumbens. The nucleus accumbens has two distinct neuronal populations that express different types of dopamine receptors: D1 and D2 neu ...

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