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New discovery in the treatment of Machado-Joseph disease

Researchers from ICVS identify cytalopram as a promising drug in the treatment of Machado-Joseph disease. The study was published in the renowned Brain journal. Machado-Joseph disease (MJD) is an inherited and currently incurable neurodegenerative disease caused by a mutation in the ATXN3 gene. When modified, this gene produces an abnormal protein (ataxin-3) that forms aggregates in neurons leading to their malfunction. This results in problems in movement coordination, balance, in speech and ...

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Do stars govern our actions? Astrocyte involvement in rodent behavior

Researchers from ICVS published a review about astrocytic function in Trends in Neurosciences. Do stars govern our actions? Astrocyte involvement in rodent behavior "Astrocytes have emerged as important partners of neurons in information processing. Important progress has been made in the past two decades to understand the role of astrocytes in the generation of neuron-astrocyte network outputs resulting in behavior. Accumulating evidence from available animal models has provided a we ...

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S100B as a Potential Biomarker and Therapeutic Target in Multiple Sclerosis

Researchers from ICVS discover S100B as a Potential Biomarker and Therapeutic Target in Multiple Sclerosis. Mol Neurobiol Barateiro et al, in press DOI 10.1007/s12035-015-9336-6 This study shows that S100b, a protein secreted by activated astrocytes whose levels are increased in the CSF and active lesions of MS patients, contributes to oligodendrocyte damage and demyelination. http://link.springer.com/article/10.1007%2Fs12035-015-9336-6

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ICVS researcher awarded by the International Association for the Study of Pain

The International Association for the study ofPain (IASP) is the leading association dedicated to the promotion of basic andclinical pain research. Through the years it has been supporting researchers,projects and a number of educational and dissemination initiatives. Amongst the winners of the 2015 Early Career Research Grants recently announced by the IASP isHugo Leite-Almeida from the Associate Laboratory ICVS/3B’s, University ofMinho. The awarded project - "Impulsive decision- ...

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ICVS researcher received the “Young Faculty Award” at 12th Alzheimer’s and Parkinson’s diseases International meeting

During the Opening Ceremony of the 12th AD/PD 2015 International Meeting, Ioannis Sotiropoulos, ICVS researcher, was awarded with the “Young Faculty Award 2015 “ presenting the work entitled “Tau missorting as part of glucocorticoid-triggered synaptic pathology”. The authors of this work are: Sara Pinheiro, Joana Silva, Cristina Mota, João Vaz-Silva, Ana Veloso, Vitor Pinto, Nuno Sousa, João Cerqueira & Ioannis Sotiropoulos. AD/PD meeting is a well-recogn ...

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