- Natural Killer Cells
- Chronic infection
“Pedro Alves-Peixoto graduated in 2021 in the joint MD/PhD program of the School of Medicine – University of Minho (EM-UM) and Thomas Jefferson University (TJU). During his PhD he focused on the effects of persistent viral infections in the subsequent immune response towards unrelated viral infections, using mouse models of infection. The work was performed under the supervision of Luis J Sigal (TJU) and Margarida Correia-Neves (EM-UM). For that, he studied the classical model of persistent infection with lymphocytic choriomeningitis virus (LCMV) in the wild-type C57BL/6 mouse, uncovering a phenotype of immune arrest with NK-cell and T-cell dysfunction, maturation and activation arrest that contributes to susceptibility to unrelated ectromelia virus (ECTV) infection in the C57BL/6 mouse, otherwise naturally resistant to ECTV infection. He acquired expertise on multicolor flow-cytometry based immunophenotyping, cell sorting, and NK-cell and T-cell functional assays, as well as tissue/ sorted cells RNA extraction, purification and qRT-PCR amplification. Since 2020, under the supervision of Cláudia Nóbrega (EM-UM) and Margarida Correia-Neves (EM-UM), Pedro Alves-Peixoto is studying the effects of HIV infection in the phenotype of NK-cells in the human and how the NK-cells would respond during subsequent antiretroviral therapy (ART). Pedro Alves-Peixoto published 8 peer-reviewed articles (2 as 1st author (Q1, IF 4.501) and 1 as 1st co-author (Q1, IF 8.986)).
Ciência ID: 6B17-D643-6C9A
ORCID iD: 0000-0002-6082-6838
Scopus ID: 57214907087”
“Pedro Alves-Peixoto; Maria Férez; Cory J. Knudson; Carolina R. Melo-Silva; Colby Stotesbury; Eric B. Wong; Margarida Correia-Neves; Luis J. Sigal; Joanna L. Shisler. “”Loss of Resistance to Mousepox during Chronic Lymphocytic Choriomeningitis Virus Infection Is Associated with Impaired T-Cell Responses and Can Be Rescued by Immunization””. Journal of Virology 94 5 (2020): https://doi.org/10.1128/JVI.01832-19.
Pedro Alves-Peixoto; Maria Férez; Cory J. Knudson; Colby Stotesbury; Carolina R. Melo-Silva; Eric B. Wong; Margarida Correia-Neves; Luis J. Sigal; Joanna L. Shisler. “”Chronic Lymphocytic Choriomeningitis Infection Causes Susceptibility to Mousepox and Impairs Natural Killer Cell Maturation and Function””. Journal of Virology (2019): https://doi.org/10.1128/JVI.01831-19.
Cory J. Knudson, Pedro Alves-Peixoto, Hiromi Muramatsu, Colby Stotesbury, Lingjuan Tang, Paulo J.C. Lin, Ying K. Tam, Drew Weissman, Norbert Pardi, Luis J. Sigal. “”Lipid-nanoparticle-encapsulated mRNA vaccines induce protective memory CD8 T cells against a lethal viral infection””. Molecular Therapy (2021): http://dx.doi.org/10.1016/j.ymthe.2021.05.011.
Colby Stotesbury; Pedro Alves-Peixoto; Brian Montoya; Maria Ferez; Savita Nair; Christopher M. Snyder; Shunchuan Zhang; Cory J. Knudson; Luis J. Sigal. “”a2ß1 Integrin Is Required for Optimal NK Cell Proliferation during Viral Infection but Not for Acquisition of Effector Functions or NK Cell–Mediated Virus Control””. The Journal of Immunology (2020): ji1900927-ji1900927. https://doi.org/10.4049/jimmunol.1900927.
Cory J. Knudson; Maria Férez; Pedro Alves-Peixoto; Dan A. Erkes; Carolina R. Melo-Silva; Lingjuan Tang; Christopher M. Snyder; Luis J. Sigal. “”Mechanisms of anti-viral Cytotoxic CD4 T cell differentiation””. Journal of Virology (2021): https://doi.org/10.1128/JVI.00566-21.
Carolina R. Melo-Silva; Gerd Sutter; Pedro Alves-Peixoto; Natasha Heath; Lingjuan Tang; Brian Montoya; Cory J. Knudson; et al. “”Resistance to lethal ectromelia virus infection requires Type I interferon receptor in natural killer cells and monocytes but not in adaptive immune or parenchymal cells””. PLOS Pathogens (2021): https://doi.org/10.1371/journal.ppat.1009593.
Maria Ferez; Cory J. Knudson; Avital Lev; Eric B. Wong; Pedro Alves-Peixoto; Lingjuan Tang; Colby Stotesbury; Luis J. Sigal. “”Viral infection modulates Qa-1b in infected and bystander cells to properly direct NK cell killing””. Journal of Experimental Medicine 218 5 (2021): https://doi.org/10.1084/jem.20201782.
C. Serre-Miranda; C. Nobrega; S. Roque; J. Canto-Gomes; C.S. Silva; N. Vieira; P. Barreira-Silva; et al. “”Performance assessment of 11 commercial serological tests for SARS-CoV-2 on hospitalised COVID-19 patients””. International Journal of Infectious Diseases 104 (2021): 661-669. https://doi.org/10.1016/j.ijid.2021.01.038.”