Cognitive deficits are common in MS but therapeutic options are lacking. Modafinil has been show to impact cognitive performance in some trials for MS-related fatigue, but it has a variable impact in different patients. The goal of this pilot phase II double-blind placebo controlled trial is to assess the efficacy and safety of modafinil in improving self-reported cognitive function. We will also try to use phMRI to identify predictors of response to modafinil.

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S. Queirós, “Right ventricular segmentation in multi-view cardiac MRI using a unified U-net model”, in E. Puyol Antón et al. (eds) Statistical Atlases and Computational Models of the Heart. Multi-Disease, Multi-View, and Multi-Center Right Ventricular Segmentation in Cardiac MRI Challenge. STACOM 2021. Lecture Notes in Computer Science, vol 13131, pp. 287-295, Springer, Cham, 2022.

“Best Paper Award in the M&Ms-2 Challenge”, by M&Ms2 Challenge organizers and the Medical Image Computing and Computer Assisted Intervention (MICCAI) Society.