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Research & Scientists | Neurosciences | People | PATRICIAMONTEIRO

 

Name: Patricia Monteiro

Office: I2.10

School Phone: +351 253 604 902

Email: patriciamonteiro@med.uminho.pt

 

 

 

Keywords: Stress OCD Autism neuroscience inhibitory networks transgenic mice electrophysiology optogenetics

About

Patricia Monteiro is a researcher in the Neuroscience Research Domain at School of Medicine, University of Minho. She holds a BSc/MSc degree in Pharmaceutical Sciences (University of Coimbra) and a PhD degree in Neurosciences (international PhD program in Experimental Biology and Biomedicine, University of Coimbra). She did her Ph.D. training with Dr. Guoping Feng at the Massachusetts Institute of Technology (2010-2015, MIT, USA), where she focused on understanding brain circuitry mechanisms underlying repetitive behaviors present in obsessive-compulsive (OCD) and autism-spectrum disorders (ASD). She also collaborated with Dr. Ann Graybiel (MIT, USA) in a study that shed light on neural circuits involved in OCD and where optogenetic stimulation was used to cut off compulsive behaviors in mice [Science, 2013]. Recently she published the reversal of autistic-like behaviors in adult mice by restoring the Shank3 gene [Nature, 2016] and coauthored another publication showing that particular human mutations in the Shank3 gene, can lead to distinct phenotype in mice, associated with distinct neuropsychiatric disorders [Neuron, 2016]. Patricia has been awarded an EMBO postdoctoral fellowship as well as a Branco Weiss Grant, to study how stress impacts brain networks. Her research at ICVS focuses on new approaches to tackle brain disorders.


The stressed brain project (Society in Science):

http://www.society-in-science.org/patricia-monteiro.html


Recent publications:


Monteiro P. and Feng G. SHANK proteins: roles at the synapse and in autism spectrum disorder.
Nature Reviews Neuroscience 18(3):147-157. 2017.

Mei Y*, Monteiro P*, Zhou Y, Kim J, Gao X, Fu Z, and Feng G. Adult restoration of Shank3 expression rescues selective autistic-like phenotypes.
Nature 530(7591):481-4. 2016.
*These authors contributed equally to this work..

Zhou Y, Kaiser T, Monteiro P, Zhang X,  Van der Goes MS, Wang D, Barak B, Zeng M, LiC, Lu C, Wells M, Amaya A, Nguyen S, Lewis M, Sanjana N, Zhou Y, Zhang M, Zhang F, Fu Z, Feng G. Shank3 mutations associated with ASD and schizophrenia display both shared and distinct defects.
Neuron 89:147-162. 2016.

Zhang Q*, Gao X*, Li C*, Feliciano C, Wang D, Zhou D, Mei Y, Monteiro P, Anand M, Itohara S, Dong X, Fu Z, Feng G. Impaired dendritic development and memory in Sorbs2 knockout mice.
The Journal of Neuroscience 17;36(7):2247-60. 2016. *These authors contributed equally to this work.

Monteiro P and Feng G. Learning from Animal Models of Obsessive-Compulsive Disorder.
Biological Psychiatry
79(1):7-16. 2016.


Burguière E, Monteiro P, Feng G and Graybiel AM. Striatal circuits, habits, and implications for obsessive-compulsive disorder.

Current Opinion in Neurobiology 30:59-65. 2015.

Kaiser T*, Ting J*, Monteiro P and Feng G. Transgenic labeling of parvalbumin-expressing neurons with tdTomato.
Neuroscience 3;321:236-45. 2015. *These authors contributed equally to this work.

Burguière E, Monteiro P, Feng G and Graybiel AM. Optogenetic Stimulation of Lateral Orbitofronto-Striatal Pathway Suppresses Compulsive Behaviors. 
Science 340(6137):1243-6. 2013.

Gomes JR*, Costa JT*, Melo CV, Felizzi F, Monteiro P, Pinto MJ, Inácio AR, Wieloch T, Almeida RD, Grãos M, Duarte CB. Excitotoxicity downregulates TrkB.FL signaling and upregulates the neuroprotective truncated TrkB receptors in cultured hippocampal and striatal neurons.
The Journal of Neuroscience 32(13):4610-22. 2012. *These authors contributed equally to this work.


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