Patricia Monteiro is currently a researcher in the Neuroscience Research Domain working togther with Professor Nuno Sousa at School of Medicine, University of Minho. She holds a licentiate degree in Pharmaceutical Sciences (University of Coimbra [FFUC]) and a PhD degree in Neurosciences (international PhD program in Experimental Biology and Biomedicine, University of Coimbra [FCTUC]). She conducted her PhD research at Dr. Feng’s lab (2010-2016, MIT, USA), where she focused on understanding brain circuitry mechanisms underlying repetitive behaviors present in obsessive-compulsive (OCD) and autism-spectrum disorders (ASD). She collaborated with Dr. Ann Graybiel (MIT) in a study that shed light on neural circuits involved in OCD and where optogenetic stimulation was used to cut off compulsive behaviors in mice. Recently she published the reversal of autistic-like behaviors in adult mice by restoring the Shank3 gene and coauthored another publication showing that particular human mutations in the Shank3 gene, can lead to distinct phenotype in mice, associated with distinct neuropsychiatric disorders. Patricia has recently been awarded an EMBO postdoctoral fellowship as well as a Branco Weiss Grant, to study the neuronal brain circuits underlying stress response. Her research at ICVS tackles new approaches in stress-related disorders and aims to provide insights into how stress impacts brain networks.
The stressed brain project (Society in Science):
Monteiro P. and Feng G. SHANK proteins: roles at the synapse and in autism spectrum disorder.
Nature Reviews Neuroscience 18(3):147-157. 2017.
Mei Y*, Monteiro P*, Zhou Y, Kim J, Gao X, Fu Z, and Feng G. Adult restoration of Shank3 expression rescues selective autistic-like phenotypes.
Nature 530(7591):481-4. 2016. *These authors contributed equally to this work..
Zhou Y, Kaiser T, Monteiro P, Zhang X, Van der Goes MS, Wang D, Barak B, Zeng M, LiC, Lu C, Wells M, Amaya A, Nguyen S, Lewis M, Sanjana N, Zhou Y, Zhang M, Zhang F, Fu Z, Feng G. Shank3 mutations associated with ASD and schizophrenia display both shared and distinct defects.
Neuron 89:147-162. 2016.
Zhang Q*, Gao X*, Li C*, Feliciano C, Wang D, Zhou D, Mei Y, Monteiro P, Anand M, Itohara S, Dong X, Fu Z, Feng G. Impaired dendritic development and memory in Sorbs2 knockout mice.
The Journal of Neuroscience 17;36(7):2247-60. 2016. *These authors contributed equally to this work.
Kaiser T*, Ting J*, Monteiro P and Feng G. Transgenic labeling of parvalbumin-expressing neurons with tdTomato.
Neuroscience 3;321:236-45. 2015. *These authors contributed equally to this work.
Burguière E, Monteiro P, Feng G and Graybiel AM. Optogenetic Stimulation of Lateral Orbitofronto-Striatal Pathway Suppresses Compulsive Behaviors.
Science 340(6137):1243-6. 2013.
Gomes JR*, Costa JT*, Melo CV, Felizzi F, Monteiro P, Pinto MJ, Inácio AR, Wieloch T, Almeida RD, Grãos M, Duarte CB. Excitotoxicity downregulates TrkB.FL signaling and upregulates the neuroprotective truncated TrkB receptors in cultured hippocampal and striatal neurons.
The Journal of Neuroscience 32(13):4610-22. 2012. *These authors contributed equally to this work.