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Obesity reduces life expectancy in future generations

In the media: Surgical Sciences researcher believes there is cause for alarm! Link>

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Astrocyte pathology in the prefrontal cortex impairs the cognitive function of rats

Interest in astroglial cells is rising due to recent findings supporting dynamic neuron-astrocyte interactions. There is increasing evidence of astrocytic dysfunction in several brain disorders such as depression, schizophrenia or bipolar disorder; importantly these pathologies are characterized by the involvement of the prefrontal cortex and by significant cognitive impairments.In the present study, to model astrocyte pathology animals were injected with the astrocyte specific toxin L-aminoad ...

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Early life maternal separation induces, in adulthood, anxious and depressive-like behavior and alterations immunological and endocrine parameters

Maternal separation (MS), an early life stressful event, has been demonstrated to trigger neuropsychiatric disorders later in life, in particular depression. However, the mechanism by which MS leads to neuropsychiatric disorders is far from being understood. In the present study, MS was induced in rats in two developmental periods: postnatal days 2–15 (MS2–15) and 7–20 (MS7–20). Behavioral, immunological, and endocrine parameters, frequently associated with depressive-lik ...

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Surgical Sciences researchers awarded at the 45th Annual Meeting of Canadian Association of Paediatric Surgeons

Research conducted by Patrícia P. Terra, Jorge Correia Pinto and collaborators was awarded the Second Prize winner for Podium presentations (oral communications) at the 45th Annual Meeting of Canadian Association of Paediatric Surgeons, Chalottetown, Prince Edward Island. “MicroRNAmiR-200b rescues abnormal branching morphogenesis of nitrofen-inducedhypoplastic lung explants” Patrícia Pereira Terra, Anouk Chantal Deden, Fuqin Zhu, BarbIwasiow, Jorge Correia Pinto, ...

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Researchers from ICVS/3Bs develop a new transgenic mouse model of Machado-Joseph disease and demonstrate a delay of the progression of the disease by 17-DMAG treatment

In a recently published work in Neurotherapeutics, a team of researchers at the Life and Health Sciences Research Institute of the University of Minho led by Prof. Patrícia Maciel and including Anabela Silva-Fernandes and Sara Duarte-Silva describe a new mouse model of Machado-Joseph disease, an inherited neurodegenerative disease caused by mutation in the ATXN3 gene, which until now remains untreatable. This transgenic mouse recapitulates several features of the human disease at the clinical an ...

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