Adriana F. Gonçalves

  • Malaria
  • Drug Resistance
  • Genetic Engineering
  • Proteasome
  • Plasmodium falciparum
  • Artemisinin

Adriana F. Gonçalves completed her BSc in Biochemistry in 2019 and her MSc in Health Sciences in 2022 at the Universidade do Minho. She is currently a PhD candidate in the ReNEU team at ICVS, under the supervision of Dr. Pedro Ferreira, and at Global Health and Tropical Medicine, Universidade Nova de Lisboa, under the supervision of Dr. Pedro Cravo. During her undergraduate and master’s research, she focused on generating genetically edited Plasmodium falciparum parasites to investigate mechanisms of resistance to antimalarial drugs. Her current doctoral research aims to elucidate the role of the proteasome in antimalarial resistance, contributing to a deeper understanding of parasite adaptation and therapeutic failure. In addition to her main research projects, she has been involved in collaborative initiatives, including “MalPharm – A genetic sensors-based high-throughput screening platform for antimalarial development” and “Mechanisms of action and resistance to the antimalarial Purydrazide.” To date, she has authored three peer-reviewed publications and presented her work at national and international scientific meetings. She has also contributed to the supervision and mentoring of undergraduate students.

Adriana F. Gonçalves

  • Malaria
  • Drug Resistance
  • Genetic Engineering
  • Proteasome
  • Plasmodium falciparum
  • Artemisinin

Adriana F. Gonçalves completed her BSc in Biochemistry in 2019 and her MSc in Health Sciences in 2022 at the Universidade do Minho. She is currently a PhD candidate in the ReNEU team at ICVS, under the supervision of Dr. Pedro Ferreira, and at Global Health and Tropical Medicine, Universidade Nova de Lisboa, under the supervision of Dr. Pedro Cravo. During her undergraduate and master’s research, she focused on generating genetically edited Plasmodium falciparum parasites to investigate mechanisms of resistance to antimalarial drugs. Her current doctoral research aims to elucidate the role of the proteasome in antimalarial resistance, contributing to a deeper understanding of parasite adaptation and therapeutic failure. In addition to her main research projects, she has been involved in collaborative initiatives, including “MalPharm – A genetic sensors-based high-throughput screening platform for antimalarial development” and “Mechanisms of action and resistance to the antimalarial Purydrazide.” To date, she has authored three peer-reviewed publications and presented her work at national and international scientific meetings. She has also contributed to the supervision and mentoring of undergraduate students.

Scientific Highlights

Gonçalves AF, Lima-Pinheiro A, Teixeira M, Cassiano GC, Cravo P and Ferreira PE (2024). Mutation in the 26S proteasome regulatory subunit rpn2 gene in Plasmodium falciparum confers resistance to artemisinin. Front. Cell. Infect. Microbiol. 14:1342856. doi: 10.3389/fcimb.2024.1342856;

Gonçalves AF, Lima-Pinheiro A and Ferreira PE (2024). Ubiquitin-proteasome system in Plasmodium: a potential antimalarial target to overcome resistance – a systematic review. Front. Med. 11:1441352. doi: 10.3389/fmed.2024.1441352;

Gonçalves, A. F., Lima-Pinheiro, A., Sampaio-Marques, B., & Ferreira, P. E. (2026). Profiling 26S Proteasome Activity of Plasmodium falciparum Monitored by a Live-Cell Assay. International Journal of Molecular Sciences, 27(5), 2104. https://doi.org/10.3390/ijms27052104

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Molecular Therapies

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