Ana Marote

  • Induced pluripotent stem cells
  • Parkinson's disease
  • Disease modeling
  • Mesenchymal Stem Cells
  • Secretome

Ana Marote completed her BSc in Biomedical Sciences in 2011 and her MSc in Molecular Biomedicine in 2013, both from the University of Aveiro. In 2020, she received her PhD in Health Sciences from the University of Minho, which was mainly focused In unveiling the therapeutic potential of induced pluripotent stem cells (iPSCs)-derived mesenchymal stem cells secretome as a cell-free therapy for Parkinson’s disease. During her PhD she was also a visiting PhD student at the iPSC Laboratory for CNS Disease Modeling at Lund University, where she trained in stem cell biology, and acquired skills necessary for the generation of iPSCs and their differentiation into midbrain dopaminergic neurons. Currently, she is a junior researcher at ICVS focused on the development of new iPSC-based in vitro models for studying Parkinson’s disease. She is currently an author of 21 papers (over 400 citations, h-index=11, Scopus), one book section and Is a reviewer for several peer-reviewed international journals, including the International Journal of Molecular Sciences and the Journal of Cellular and Molecular Medicine. She was also part of the Organizing Committee of the 1st international symposium Secretome With]Out[ Borders (2018) and 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (2022).

Scientific Highlights

2020: Salgado, António J.; Marote, Ana; Pinto, Luisa; Mendes-Pinheiro, Bárbara. 2020. “”Compositions for therapy or treatment of Parkinson’s disease, methods and uses thereof””. (Registered patent)
2019: FENS travel grant,
2016: Marote, A., et al. MSCs-Derived Exosomes: Cell-Secreted Nanovesicles with Regenerative Potential. Frontiers in Pharmacology 2016, 7 (231) – Web of Science Top 1%, as one of the most cited of the field (over 147 citations)
2015: PhD scholarship – PDE/BDE/113598/2015 in FCT PhD program in Applied Health Sciences (PhDiHES)

Projects

Basic mechanisms of degeneration/regeneration

This project dedicates to fundamental research to understand the molecular mechanisms underlying Parkinson’s Disease (PD) and Spinal Cord Injury (SCI) pathophysiology.

In the context of PD, we focus on addressing how…

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