Belém Sampaio-Marques

  • Aging
  • Age-associated diseases
  • Proteostasis
  • Synucleinopathies
  • Metabolism

Belém Sampaio Marques graduated in 2003 in Biology at Azores University and received a PhD in Health Sciences from University of Minho in 2012. Between 2013 and 2019 she developed postdoctoral studies on the study and elucidation of mechanisms associated with aging and aged-related diseases, using the yeast Saccharomyces cerevisiae as a model for neurodegenerative diseases, namely for Parkinson diseases, at the Life and Health Sciences Research Institute (ICVS) of the University of Minho. Since 2019, she is a Junior Researcher at ICVS and also an Assistant professor (20%) at school of Medicine, University of Minho. Her research activity is focused on the elucidation of the molecular mechanisms and cellular processes of aging and age-associated diseases. More recently, she is also involved in other research topics, namely in investigating the mechanism underlying the development, progression, relapse and chemoresistance of acute myeloid leukemia (AML). Her track record is currently mirrored by 41 publications in international peer-reviewed journals (>1300 citations and h-index=18, Scopus; February 2022), and 2 book chapter. She is supervising 1 PhD and 5 MSc (three already finished) thesis. She has been an ad-hoc reviewer for more than 20 journals and some funding agencies. Belém received 5 awards and/or honors.

Belém Sampaio-Marques

  • Aging
  • Age-associated diseases
  • Proteostasis
  • Synucleinopathies
  • Metabolism

Belém Sampaio Marques graduated in 2003 in Biology at Azores University and received a PhD in Health Sciences from University of Minho in 2012. Between 2013 and 2019 she developed postdoctoral studies on the study and elucidation of mechanisms associated with aging and aged-related diseases, using the yeast Saccharomyces cerevisiae as a model for neurodegenerative diseases, namely for Parkinson diseases, at the Life and Health Sciences Research Institute (ICVS) of the University of Minho. Since 2019, she is a Junior Researcher at ICVS and also an Assistant professor (20%) at school of Medicine, University of Minho. Her research activity is focused on the elucidation of the molecular mechanisms and cellular processes of aging and age-associated diseases. More recently, she is also involved in other research topics, namely in investigating the mechanism underlying the development, progression, relapse and chemoresistance of acute myeloid leukemia (AML). Her track record is currently mirrored by 41 publications in international peer-reviewed journals (>1300 citations and h-index=18, Scopus; February 2022), and 2 book chapter. She is supervising 1 PhD and 5 MSc (three already finished) thesis. She has been an ad-hoc reviewer for more than 20 journals and some funding agencies. Belém received 5 awards and/or honors.

Scientific Highlights

1. Pioneer in using the yeast chronological aging model to study the effects of apha-synuclein expression;

2. Contribution for the demostrations that expression of the Parkinson´s disease associated protein, alpha-synuclein, in aged cells drives to an overactivation of autophagy and mitophagy that results in premature aging;

3. Characterization of the molecular machanisms associated with the expression of apha-synuclein;

4. Contribution for the study of metabolomics changes in Acute Myeloid Leukemia.

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Projects

As Leader

Projects

As Member

Immunometabolic requirements in Buruli Ulcer

Mycobacterium ulcerans is the causative agent of Buruli Ulcer (BU), a neglected tropical disease characterized by extensive necrotic skin lesions. M. ulcerans, although an intracellular pathogen, is able to secrete a cytotoxic and immunosuppressive toxin – mycolactone…

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Novel Biomarkers in Fabry disease Progression

Fabry disease (FD) a is multi-systemic, X-linked lysosomal storage disease caused by a range of mutations in the GLA gene that encodes for alpha-galactosidase A (α-gal A). Mutations leading to a deficient or absent activity of the enzyme α-gal A result in a progressive accumulation…

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