Jonas de Oliveira Campos has a BSc in Nutrition Sciences by the São Camilo University Center and a Master’s degree in Biochemistry by the University of Beira Interior. Currently, he is a researcher at the Life and Health Sciences Research Institute in the School of Medicine at the University of Minho. His work is centered on the development and study of the combined use of Mesenchymal Stem Cell secretome and the dietary omega-3 fatty acid Docosahexaenoic Acid (DHA) to promote regeneration for spinal cord injury. He is interested in the mechanistic understanding of how nutritional compounds and dietary interventions modulate stem cell function with the ultimate goal of leveraging this understanding for the development of regenerative strategies and therapies for neurological diseases.
Jonas de Oliveira Campos has a BSc in Nutrition Sciences by the São Camilo University Center and a Master’s degree in Biochemistry by the University of Beira Interior. Currently, he is a researcher at the Life and Health Sciences Research Institute in the School of Medicine at the University of Minho. His work is centered on the development and study of the combined use of Mesenchymal Stem Cell secretome and the dietary omega-3 fatty acid Docosahexaenoic Acid (DHA) to promote regeneration for spinal cord injury. He is interested in the mechanistic understanding of how nutritional compounds and dietary interventions modulate stem cell function with the ultimate goal of leveraging this understanding for the development of regenerative strategies and therapies for neurological diseases.
Secretome of bone marrow mesenchymal stromal cells cultured in a dynamic system induces neuroprotection and modulates microglial responsiveness in an α-synuclein overexpression rat model. Cytotherapy. 2024 Jul;26(7):700-713. doi: 10.1016/j.jcyt.2024.02.008.
Human platelet lysate supports SH-SY5Y neuroblastoma cell proliferation and differentiation into a dopaminergic-like neuronal phenotype under xenogeneic-free culture conditions. Biotechnol J. 2024 Jul;19(7):e2400068. doi: 10.1002/biot.202400068.
In vitro neuronal and glial response to magnetically stimulated piezoelectric poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV)/cobalt ferrite (CFO) microspheres. Biomater Adv. 2024 May;159:213798. doi: 10.1016/j.bioadv.2024.213798.
Glucocorticoid receptor-dependent therapeutic efficacy of tauroursodeoxycholic acid in preclinical models of spinocerebellar ataxia type 3. J Clin Invest. 2024 Mar 1;134(5). doi:
The secretome of macrophages has a differential impact on spinal cord injury recovery according to the polarization protocol. Front Immunol. 2024;15:1354479. doi: 10.3389/fimmu.2024.1354479. 10.1172/JCI162246.
Adipose tissue derived stem cell secretome induces motor and histological gains after complete spinal cord injury in Xenopus laevis and mice. J Tissue Eng. 2024 Jan-Dec;15:20417314231203824. doi: 10.1177/20417314231203824.
Treating Parkinson’s Disease with Human Bone Marrow Mesenchymal Stem Cell Secretome: A Translational Investigation Using Human Brain Organoids and Different Routes of In Vivo Administration. Cells. 2023 Nov 2;12(21). doi: 10.3390/cells12212565.
Pre-Clinical Assessment of Roflumilast Therapy in a Thoracic Model of Spinal Cord Injury. Pharmaceutics. 2023 May 21;15(5). doi: 10.3390/pharmaceutics15051556.
Neurodifferentiation and Neuroprotection Potential of Mesenchymal Stromal Cell-Derived Secretome Produced in Different Dynamic Systems. Biomedicines. 2023 Apr 22;11(5). doi: 10.3390/biomedicines11051240.
Cerebral Malaria Model Applying Human Brain Organoids. Cells. 2023 Mar 23;12(7). doi: 10.3390/cells12070984. Co-author (Surgery and Post-operative work, behavioral analysis, Tissue dissection)
Acute baclofen administration promotes functional recovery after spinal cord injury. Spine J. 2023 Mar;23(3):379-391. doi: 10.1016/j.spinee.2022.09.007.
Spinal cord RNA-seq data after a baclofen treatment in mice with a spinal cord injury. Data Brief. 2023 Feb;46:108809. doi: 10.1016/j.dib.2022.108809.
Cellular Aging Secretes: a Comparison of Bone-Marrow-Derived and Induced Mesenchymal Stem Cells and Their Secretome Over Long-Term Culture. Stem Cell Rev Rep. 2023 Jan;19(1):248-263. doi: 10.1007/s12015-022-10453-6.
Cerebral Organoids to Study Central Mechanisms of Pain: The Effect of Stem Cell Secretome on Opioid Receptors and Neuroplasticity. Stem Cells Dev. 2022 Oct;31(19-20):641-657. doi: 10.1089/scd.2022.0116.
Microglial Depletion Has No Impact on Disease Progression in a Mouse Model of Machado-Joseph Disease. Cells. 2022 Jun 25;11(13). doi: 10.3390/cells11132022.
Nutritional interventions for spinal cord injury: preclinical efficacy and molecular mechanisms. Nutr Rev. 2022 Apr 8;80(5):1206-1221. doi: 10.1093/nutrit/nuab068. Review. PubMed PMID: 34472615.
Unilateral Intrastriatal 6-Hydroxydopamine Lesion in Mice: A Closer Look into Non-Motor Phenotype and Glial Response. Int J Mol Sci. 2021 Oct 26;22(21). doi: 10.3390/ijms222111530.
Fractionating stem cells secretome for Parkinson’s disease modeling: Is it the whole better than the sum of its parts?. Biochimie. 2021 Oct;189:87-98. doi: 10.1016/j.biochi.2021.06.008.
Astrocyte signaling impacts the effects of human bone marrow mesenchymal stem cells secretome application into the hippocampus: A proliferation and morphometrical analysis on astrocytic cell populations. Brain Res. 2020 Apr 1;1732:146700. 10.1016/j.brainres.2020.146700. Epub 2020 Feb 4. Review. PubMed PMID: 32032613.
Preclinical Comparison of Stem Cells Secretome and Levodopa Application in a 6 Hydroxydopamine Rat Model of Parkinson’s Disease. Cells. 2020 Jan 28;9(2). doi: 10.3390/cells9020315.
Awards
Best Poster Award – 3rd Place at the Portuguese Society of Stem Cells and Cell Therapies and European Tissue Regeneration Society joint conference, Portugal, 2023
Prize awarded for the best basic research publication in the field pain research in 2022 (Grunenthal Foundation) Portugal, 2023
Best Poster Presentation Award – 1st Place at the Portuguese Network for Glial Cells Researchers – VIII Symposium Portuguese Network of Glial Cells Researchers, Portugal, 2024
This project dedicates to fundamental research to understand the molecular mechanisms underlying Parkinson’s Disease (PD) and Spinal Cord Injury (SCI) pathophysiology.
In the context of PD, we focus on addressing how…
Recent advances in the field of electronics, miniaturisation and microfabrication and a deeper understanding of the interface between physics and living matter for sensing and neural stimulation allow us to develop new…
The remarkable advances in molecular biology in the past decades have led to a better understanding of the mechanisms implicated in the pathophysiology of many CNS disorders as well as mechanisms that control axonal regeneration…
We have previously validated the use of the secretome of Mesenchymal Stem Cells (MSCs) from different sources, including those derived from pluripotent stem cells (iMSCs), as a possible therapeutic tool in animal…
Phone: +351 253 604 967
Fax: +351 253 604 809
Email: icvs.sec@med.uminho.pt
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
Copyright ©2022 ICVS. All Rights Reserved
Copyright ©2022 ICVS. All Rights Reserved
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
Copyright ©2022 ICVS. All Rights Reserved
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
