Rute S Moura

  • lung development
  • branching morphogenesis
  • chicken embryo
  • in ovo model
  • signaling pathways
  • metabolism

Rute S Moura holds a degree in Biochemistry from the University of Porto and a Ph.D. in Biological Sciences from the University of León (Spain). Currently, she is an Affiliated Researcher at the Surgical Sciences and Allied Technologies Team. Her research interests include the study of molecular mechanisms involved in lung development, namely signaling pathways relevant for normal/abnormal pulmonary development, using the chicken embryo as a model. She has characterized the molecular mechanisms underlying early chick lung development and contributed to establishing the avian lung as a surrogate to the mammalian models to study branching morphogenesis. More recently, she has been interested in studying the interplay between signaling and metabolism during early pulmonary development, and exploring the potential of the in ovo model to mimic conditions that impair embryonic development, for instance, hyperglycemia.

Scientific Highlights

2023. Silva-Ribeiro T, Coelho E, Genisheva Z, Oliveira JM, Correia-Pinto J, Sampaio P, Moura RS. Comparative study of e-cigarette aerosol and cigarette smoke effect on ex vivo embryonic chick lung explants. Toxicol Lett. doi:10.1016/j.toxlet.2023.01.002
2022. Barbosa VB, Costa-Silva PF, Araújo-Silva H, Miranda G, Correia-Pinto J, Moura RS. Molecular insights of Hippo signaling in the chick developing lung. Biochim Biophys Acta Gene Regul Mech. 1866(1):194904. doi:10.1016/j.bbagrm.2022.194904
2021. Caldeira I, Fernandes-Silva H, Machado-Costa D, Correia-Pinto J, Moura RS. Developmental Pathways Underlying Lung Development and Congenital Lung Disorders. Cells 10(11):2987. doi: 10.3390/cells1011298
2021. Fernandes-Silva H, Alves MG, Araújo-Silva H, Silva AM, Correia-Pinto J, Oliveira PF, Moura RS. Lung branching morphogenesis is accompanied by temporal metabolic changes towards a glycolytic preference. Cell Biosci 11:134. doi:10.1186/s13578-021-00654-w
2020. Fernandes-Silva H, Araújo-Silva H, Correia-Pinto J, Moura RS. Retinoic Acid: A Key Regulator of Lung Development. Biomolecules, 10(1):152. doi:10.3390/biom10010152
2019. Moura RS. “Retinoic Acid as a Modulator of Proximal-Distal Patterning and Branching Morphogenesis of the Avian Lung”” in Retinoid and Rexinoid Signaling: Methods and Protocols. Methods in Molecular Biology. Ray SK (Ed), Springer Nature. Chap 15, 209-224. doi:10.1007/978-1-4939-9585-1_15.
2017. Fernandes-Silva H, Vaz-Cunha P, Barbosa VB, Silva-Gonçalves C, Correia-Pinto J, Moura RS. Retinoic acid regulates avian lung branching through a molecular network. Cell Mol Life Sci, 74(24):4599-4619. doi:10.1007/s00018-017-2600-3.
2017. Fernandes-Silva H, Correia-Pinto J, Moura RS. Canonical Sonic Hedgehog Signaling in Early Lung Development. J Dev Biol. 5(1):3. doi:10.3390/jdb5010003
2017. Moura RS, Correia-Pinto J. “”Molecular aspects of avian lung development”” in The Biology of the Avian Respiratory System: Evolution, Development, Structure and Function. Maina JN (Ed); Springer International Publishing. Chap 5, 129-146. doi:10.1007/978-3-319-44153-5_5.