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Globally prevalent mutations in Plasmodium falciparum modulate susceptibility to artemisinin-based combination therapies.

Main findings Artemisinin-based combination therapies (ACTs) have been highly effective in recent years in treating Plasmodium falciparum infections and reducing the global burden of malaria. The parasite transporter protein, P. falciparum multidrug resistance 1 protein (PfMDR1), has been long observed in molecular epidemiological studies to associate with altered parasite susceptibility to multiple ACT partner drugs. Leveraging recent advances in P. falciparum genome editing via the use of zi ...

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L’Óreal For Women in Science Award granted to ICVS scientist

Isabel Veiga, researcher with the University of Minho’s Life and  ICVS, was awarded a L’Óreal Portugal Medal of Honour at the Pavilion of Knowledge in Lisbon. The scientist will receive € 15 thousand to study the resistance mechanisms the malaria parasite acquires, leading to nearly half a million deaths per year.  This award is the result of a partnership between L’Óreal Portugal, UNESCO and the Fundação para a Ciência e a Tecnologi ...

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The importance of microbiota in the first 1000 days.

The importance of microbiota in the first 1000 days.  

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A new window open up for cervical cancer: HER inhibitors could be very effective in the treatment of some of this patients.

Main findings In this study we performed the most comprehensive analysis of HER family receptor alterations in cervical cancer. We described that HER2 protein is an independent prognostic marker for these patients. Importantly, by in vitro and in vivo approaches, we showed that HER2 inhibitors are effective in reducing cervical cancer aggressiveness, similar to what happens for breast cancer patients. Moreover, combination of these drugs with glucose uptake blockers is able to overcome a putati ...

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Patrícia Gomes, a medical student & ICVS researcher, won the 1rst prize of Fundação AstraZeneca Innovate Competition for Basic Research.

During the 8th iMed Conference, Patrícia Gomes, medical student and ICVS researcher of the Neurosceince Research Domain, won the 1rst prize of Fundação AstraZeneca Innovate Competition for Basic Research, presenting the work entitled “Identifying the role of Tau protein in the molecular mechanisms of post-anesthesia cognitive deficits”. The authors of this work are: Patrícia Gomes, Joana Silva, Damiana Pires, Nuno Sousa, Hugo Leite-Almeida & Ioannis Sotiropoul ...

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