Scientific Highlights

Articles: 1.Tavares, H; Beatriz, M; Gonçalves, O; Deus, CM; Gaspar, R; Benfeito, A; Cágide, F, Borges, F; Milosevic, I; Seibler, P; Klein, C; Esteves, AR; Cardoso, SM; Pinheiro, P; Oliveira, P; Lopes, C. Micronuclear collapse under oxidative stress drives amphisome-mediated export of DNA in Parkinson’s disease. bioRxiv 2025.11.30.691376; doi: https://www.biorxiv.org/content/10.64898/2025.11.30.691376v1?ct=
2.Lopes, C# (2025). Conclusions and future perspectives. Lopes, C., Pinheiro, P (eds) Extracellular Mitochondria in Health and Disease, (1st ed.) https://doi.org/10.1016/B978-0-443-29283-5.00008-X
3. D’Acunzo, P, Levy, E, Lopes, C. (2025) Modern techniques for studying extracellular mitochondria and mitochondria-derived EVs. Lopes, C., Pinheiro, P (eds) Extracellular Mitochondria in Health and Disease, (1st ed.) https://doi.org/10.1016/B978-0-443-29283-5.00003-0
4.Lopes, C. (2024) Imaging mitochondrial axonal transport in human induced pluripotent stem cell-derived neurons. Palmeira, C., Oliveira, P (eds) Mitochondrial Bioenergetics: Methods and Protocols, (3rd ed.) Edition (Part of the book series: Methods in Molecular Biology) https://doi.org/10.1007/978-1-0716-4264-1_10
5.Lopes, C, Raimundo, N. Mitochondria-lysosome crosstalk, in disease and in health. Reichert, A.S. (Ed.). (2024). The Dynamic Nature of Mitochondria: from Ultrastructure to Health and Disease (1st ed.). CRC Press. https://doi.org/10.1201/9781003221180
6.Beatriz, Margarida; Rodrigues, Ricardo; Vilaca, Rita; Rego, Conceição, Egas; Pinheiro, Paulo; Daley, George Q; Schlaeger, Throsten M; Rego, Ana Cristina; Lopes, Carla#. Extracellular vesicles improve GABAergic transmission in Huntington’s disease iPSC-derived neurons. Theranostics. 2023 Jun 26;13(11):3707-3724. https://doi.org/10.7150/thno.81981.
7.Beatriz, Margarida; Vilaca, Rita; Anjo, Sandra I.; Manadas, Bruno; Rego, Ana Cristina; Lopes, Carla#. Defective mitochondria-lysosomal axis enhances the release of extracellular vesicles containing mitochondrial DNA and proteins in Huntington’s disease. J of Extracellular Bio. 2022;1:e65. http://dx.doi.org/10.1002/jex2.65. (ISEV-waiting IF) Q1).
8.Deus, C. M., Tavares, H., Beatriz, M., Mota, S., Lopes, C. (2022). Mitochondrial Damage-Associated Molecular Patterns Content in Extracellular Vesicles Promotes Early Inflammation in Neurodegenerative Disorders. Cells, 11(15), 2364. https://doi.org/10.3390/cells11152364.
9.Lopes, C., Ferreira, I. L., Maranga, C., Beatriz, M., Mota, S. I., Sereno, J., Castelhano, J., Abrunhosa, A., Oliveira, F., De Rosa, M., Hayden, M., Laço, M. N., Januário, C., Castelo Branco, M., & Rego, A. C. (2022). Mitochondrial and redox modifications in early stages of Huntington’s disease. Redox biology, 56, 102424. https://doi.org/10.1016/j.redox.2022.102424.
10.Beatriz, Margarida; Vilaça, Rita; Lopes, Carla#. Exosomes: Innocent Bystanders or Critical Culprits in Neurodegenerative Diseases. Front Cell Dev Biol. 2021;9:635104. https://doi.org/10.3389/fcell.2021.635104.14. 11. Lopes, Carla; Tang, Yang; Anjo, Sandra I.; Manadas, Bruno; Onofre, Isabel; de Almeida, Luís P.; Daley, George Q.; Schlaeger, Thorsten M.; Rego, Ana Cristina Carvalho. Mitochondrial and Redox Modifications in Huntington Disease Induced Pluripotent Stem Cells Rescued by CRISPR/Cas9 CAGs Targeting. Front Cell Dev Biol. 2020;8:576592. https://doi.org/10.3389/fcell.2020.576592. Awards: Scientific Contribution Award 2025 at the 2nd World Congress on Targeting Extracellular Vesicles, Valencia, Spain; FCT Mobility Programme 1st edition; EMBO Scientific Exchange Grant (University of Groningen)