Jonas Campos

  • Stem cell biology
  • metabolism
  • neuroscience
  • nutrition
  • Parkinsons Disease
  • spinal cord injury
  • Parkinson’s disease

Jonas de Oliveira Campos has a BSc in Nutrition Sciences by the São Camilo University Center and a Master’s degree in Biochemistry by the University of Beira Interior. He performed his PhD studies in Health Sciences at the School of Medicine of University of Minho under the supervision of Dr António Salgado (UMinho-Portugal) and Adina T. Michael-Titus (QMUL-UK), developing novel molecular priming approaches to improve the functionality of Mesenchymal stromal cells for regenerative applications in central nervous system disorders.  Currently, he is a post-doctoral researcher at the Life and Health Sciences Research Institute in the School of Medicine at the University of Minho. His work is centered on the development and study of the combined use of Mesenchymal Stem Cell secretome and the dietary omega-3 fatty acid Docosahexaenoic Acid (DHA) to promote regeneration for spinal cord injury. He is interested in the mechanistic understanding of how nutritional compounds and dietary interventions modulate stem cell function with the ultimate goal of leveraging this understanding for the development of regenerative strategies and therapies for neurological diseases.

Jonas Campos

  • Stem cell biology
  • metabolism
  • neuroscience
  • nutrition
  • Parkinsons Disease
  • spinal cord injury
  • Parkinson’s disease

Jonas de Oliveira Campos has a BSc in Nutrition Sciences by the São Camilo University Center and a Master’s degree in Biochemistry by the University of Beira Interior. He performed his PhD studies in Health Sciences at the School of Medicine of University of Minho under the supervision of Dr António Salgado (UMinho-Portugal) and Adina T. Michael-Titus (QMUL-UK), developing novel molecular priming approaches to improve the functionality of Mesenchymal stromal cells for regenerative applications in central nervous system disorders.  Currently, he is a post-doctoral researcher at the Life and Health Sciences Research Institute in the School of Medicine at the University of Minho. His work is centered on the development and study of the combined use of Mesenchymal Stem Cell secretome and the dietary omega-3 fatty acid Docosahexaenoic Acid (DHA) to promote regeneration for spinal cord injury. He is interested in the mechanistic understanding of how nutritional compounds and dietary interventions modulate stem cell function with the ultimate goal of leveraging this understanding for the development of regenerative strategies and therapies for neurological diseases.

Scientific Highlights

Campos J, Palha AT, Fernandes LS, et al. Modeling Spinal Cord Injury in a Dish with Hyperosmotic Stress: Population-Specific Effects and the Modulatory Role of Mesenchymal Stromal Cell Secretome. International Journal of Molecular Sciences 2025; 26: 3298.

Campos J, Sampaio-Marques B, Santos D, et al. Lipid Priming of Adipose Mesenchymal Stromal Cells with Docosahexaenoic Acid: Impact on Cell Differentiation, Senescence and the Secretome Neuroregulatory Profile. Tissue Eng Regen Med. Epub ahead of print 4 November 2024.

Marques CR*, Campos J*, Sampaio-Marques B, et al. Secretome of bone marrow mesenchymal stromal cells cultured in a dynamic system induces neuroprotection and modulates microglial responsiveness in an α-synuclein overexpression rat model. Cytotherapy; 0. Epub ahead of print 13 March 2024.

Mendes-Pinheiro B*, Campos J*, Marote A, et al. Treating Parkinson’s Disease with Human Bone Marrow Mesenchymal Stem Cell Secretome: A Translational Investigation Using Human Brain Organoids and Different Routes of In Vivo Administration. Cells 2023; 12: 2565.

Fernandes AM*, Campos J*, Silva D, et al. Cerebral Organoids to Study Central Mechanisms of Pain: The Effect of Stem Cell Secretome on Opioid Receptors and Neuroplasticity. Stem Cells Dev 2022; 31: 641–657.

Campos J, Silva NA, Salgado AJ. Nutritional interventions for spinal cord injury: preclinical efficacy and molecular mechanisms. Nutr Rev 2022; 80: 1206–1221.

Campos J, Guerra-Gomes S, Serra SC, et al. Astrocyte signaling impacts the effects of human bone marrow mesenchymal stem cells secretome application into the hippocampus: A proliferation and morphometrical analysis on astrocytic cell populations. Brain Res 2020; 1732: 146700.

 

Awards

Best Poster Award – 3rd Place at the Portuguese Society of Stem Cells and Cell Therapies and European Tissue Regeneration Society joint conference, Portugal, 2023

Prize awarded for the best basic research publication in the field pain research in 2022 (Grunenthal Foundation) Portugal, 2023

Best Poster Presentation Award – 1st Place at the Portuguese Network for Glial Cells Researchers – VIII Symposium Portuguese Network of Glial Cells Researchers, Portugal, 2024

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Projects

As Leader

Projects

As Member

Basic mechanisms of degeneration/regeneration

This project dedicates to fundamental research to understand the molecular mechanisms underlying Parkinson’s Disease (PD) and Spinal Cord Injury (SCI) pathophysiology.

In the context of PD, we focus on addressing how…

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Enabling Technologies in CNS Repair

Recent advances in the field of electronics, miniaturisation and microfabrication and a deeper understanding of the interface between physics and living matter for sensing and neural stimulation allow us to develop new…

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Molecular Therapies

The remarkable advances in molecular biology in the past decades have led to a better understanding of the mechanisms implicated in the pathophysiology of many CNS disorders as well as mechanisms that control axonal regeneration…

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