Recent advances in the field of electronics, miniaturisation and microfabrication and a deeper understanding of the interface between physics and living matter for sensing and neural stimulation allow us to develop new devices and instruments for monitoring or modulating the nervous tissue. This projects aims to take advantage of these advances in the electronics field, develop innovative medical devices that will respect the temporal dynamics of the disease and improve current static therapies (collaborations with Alar Ainla from INL and Ronalido Ichyiama, Leeds university). Namely, we aim to: 1) Understand the role of electric stimulation on processes such as neurite outgrowth, remyelination, glial cell activation and viability, underpinning some of the basic mechanisms associated; 2) Further reinforce the use of our previously developed in vitro stimulator device, as a new platform for testing the effects of electrical stimulation on different cells and tissues; 3) establish combinatory routes to deliver secretome and epidural stimulation and 4) Create novel implantable devices capable of combining electrical stimulation, tissue sensing and local drug delivery to treat the injured spinal cord (collaboration with Senentxu Lanceros-Mendez (BCMaterials – Bilbao, Spain).