Nuno A. Silva

  • Neurotrauma
  • Spinal Cord Injury
  • Molecular Therapy
  • Cell Therapy
  • Preclinical Trials

I established my team at ICVS/School of Medicine in 2014, after being able to capture national competitive funding. The focus of my lab has centered on spinal cord injury, delving into fundamental aspects of its pathophysiology and exploring novel therapeutic approaches for repair. To date (07/12/2023), I have authored 56 scientific publications, with 42 directly related to regenerative medicine for SCI, and I was the senior author in 13 of them. My work has currently more than 2900 citations and an h-index of 23. Additionally, I am the author of two patents. My team is presently constituted by 1 post-doctoral fellow, 5 PhD students, 2 MSc students and 3 technicians. Finally, during my research career, I was able to capture more than two and a half million euros of competitive funding, either in research projects (1.8M) or salary grants (706K). Notably, the international recognition includes funding from prestigious entities such as the Wings for Life and the La Caixa Foundation. Furthermore, I achieved the top ranking in the biotechnology panel of the highly competitive Portuguese government FCT CEEC call in 2023.

Nuno A. Silva

  • Neurotrauma
  • Spinal Cord Injury
  • Molecular Therapy
  • Cell Therapy
  • Preclinical Trials

I established my team at ICVS/School of Medicine in 2014, after being able to capture national competitive funding. The focus of my lab has centered on spinal cord injury, delving into fundamental aspects of its pathophysiology and exploring novel therapeutic approaches for repair. To date (07/12/2023), I have authored 56 scientific publications, with 42 directly related to regenerative medicine for SCI, and I was the senior author in 13 of them. My work has currently more than 2900 citations and an h-index of 23. Additionally, I am the author of two patents. My team is presently constituted by 1 post-doctoral fellow, 5 PhD students, 2 MSc students and 3 technicians. Finally, during my research career, I was able to capture more than two and a half million euros of competitive funding, either in research projects (1.8M) or salary grants (706K). Notably, the international recognition includes funding from prestigious entities such as the Wings for Life and the La Caixa Foundation. Furthermore, I achieved the top ranking in the biotechnology panel of the highly competitive Portuguese government FCT CEEC call in 2023.

Scientific Highlights

2023: Project Leader of the La Caixa Health Research Project “Wireless Neural Guidance Device for Spinal Cord Injury Regeneration”, Funding: 1 million euros.

2023: Project Leader of the Wing for Life Project “Activated Macrophages and Spinal Cord Injury Repair: The Secretome Effect”, Funding: 200K.

2022: Utility Patent “Electric stimulator for cell culture, device, methods and uses thereof”, PT117579A

2021: Rui Lima, …, and Nuno A. Silva, “Levetiracetam treatment leads to functional recovery after thoracic or cervical injuries of the spinal cord”. npj Regenerative Medicine: https://doi.org/10.1038/s41536-021-00121-7

2021: International Patent “Compositions for treatment of spinal cord injury, methods and uses thereof”, WO2021/108909A1

2020: Susana Monteiro, …, and Nuno A. Silva, “Splenic sympathetic signaling contributes to acute neutrophil infiltration of the injured spinal cord”. Journal of Neuroinflammation 17 1: http://dx.doi.org/10.1186/s12974-020-01945-8

2019: Meeting Chair of the 1st International Meeting of the Portuguese Network for Spinal Cord Injury Research, Braga, Portugal.

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Projects

As Leader

Enabling Technologies in CNS Repair

Recent advances in the field of electronics, miniaturisation and microfabrication and a deeper understanding of the interface between physics and living matter for sensing and neural stimulation allow us to develop new…

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Molecular Therapies

The remarkable advances in molecular biology in the past decades have led to a better understanding of the mechanisms implicated in the pathophysiology of many CNS disorders as well as mechanisms that control axonal regeneration…

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Projects

As Member

Basic mechanisms of degeneration/regeneration

This project dedicates to fundamental research to understand the molecular mechanisms underlying Parkinson’s Disease (PD) and Spinal Cord Injury (SCI) pathophysiology.

In the context of PD, we focus on addressing how…

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