Ana João Rodrigues

  • reward
  • aversion
  • neuronal circuits
  • depression
  • addiction
  • PTSD
  • nucleus accumbens
  • mesolimbic circuit
  • opioids
My research is focused in unravelling how our brain encodes rewarding and aversive events to drive motivated behaviors.
How do our brains compute that a stimulus is “good” or “bad”? How is valence represented in the mammalian brain? What are the neural substrates underlying a rewarding or an aversive experience? What lies between the stimulus and the behavioural response?
On top of these exciting fundamental neuroscience questions, I am also exploring how stress in specific developmental windows can imprint long-lasting marks in these processes, leading to maladaptive behaviours (depression, addiction).
My team uses a multidisciplinary approach, combining behavioral assessments, optogenetics, electrophysiology, pharmacology, and live imaging with genetically-encoded sensors in rodent models to understand how reward and aversion are encoded in the brain. Our research excellence has been recognized through prestigious awards, including the inaugural Janssen Neuroscience Prize, and competitive funding from the La Caixa Foundation and a European Research Council (ERC) Consolidator Grant. Beyond research, I am deeply committed to science communication and public engagement, having led multiple initiatives over several years to promote scientific literacy in the general public.

In addition to my scientific and teaching activities, I am also one of the Science Outreach Coordinators of host institution, responsible for science dissemination for the society.

Ana João Rodrigues

  • reward
  • aversion
  • neuronal circuits
  • depression
  • addiction
  • PTSD
  • nucleus accumbens
  • mesolimbic circuit
  • opioids
My research is focused in unravelling how our brain encodes rewarding and aversive events to drive motivated behaviors.
How do our brains compute that a stimulus is “good” or “bad”? How is valence represented in the mammalian brain? What are the neural substrates underlying a rewarding or an aversive experience? What lies between the stimulus and the behavioural response?
On top of these exciting fundamental neuroscience questions, I am also exploring how stress in specific developmental windows can imprint long-lasting marks in these processes, leading to maladaptive behaviours (depression, addiction).
My team uses a multidisciplinary approach, combining behavioral assessments, optogenetics, electrophysiology, pharmacology, and live imaging with genetically-encoded sensors in rodent models to understand how reward and aversion are encoded in the brain. Our research excellence has been recognized through prestigious awards, including the inaugural Janssen Neuroscience Prize, and competitive funding from the La Caixa Foundation and a European Research Council (ERC) Consolidator Grant. Beyond research, I am deeply committed to science communication and public engagement, having led multiple initiatives over several years to promote scientific literacy in the general public.

In addition to my scientific and teaching activities, I am also one of the Science Outreach Coordinators of host institution, responsible for science dissemination for the society.

Scientific Highlights

1. Domingues, Carvalho et al, Dynamic representation of appetitive and aversive stimuli in nucleus accumbens shell D1- and D2-medium spiny neurons. Nature communications (2025)
https://doi.org/10.1038/s41467-024-55269-9
2. Soares-Cunha et al, Distinct role of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior. Cell Reports (2022)
https://doi.org/10.1016/j.celrep.2022.110380
3. Coimbra B, et al. Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors. Nature Communications (2019)
https://doi.org/10.1038/s41467-019-11557-3
4. Soares-Cunha C, et al. Nucleus accumbens medium spiny neurons subtypes signal both reward and aversion. Molecular Psychiatry (2019)
https://doi.org/10.1038/s41380-019-0484-3
5. Soares-Cunha C, et al. “Nucleus accumbens microcircuit underlying D2-MSN-driven increase in motivation”. eNeuro (2018)
https://10.1523/ENEURO.0386-18.2018
6. Soares-Cunha C, et al. “Activation of D2 dopamine receptor-expressing neurons in the nucleus accumbens increases motivation. Nature Communications”. (2016)
https://10.1038/ncomms11829
7. Science outreach in national media – Researchers win a millionaire scholarship to study the brain; https://www.rtp.pt/noticias/pais/equipa-da-universidade-do-minho-garante-bolsa-de-2-milhoes-de-euros_v1297263
8. ERC consolidator – Valence; https://cordis.europa.eu/project/id/101003187
9. Science outreach in national media – “Mentes que brilham (Shining minds)” Programe participation https://portocanal.sapo.pt/um_video/zfI00IeO94CMe6ERV3ub
10. Science outreach in national media – Interview about the way our brain encodes positive and negative information – https://observador.pt/2021/03/19/os-neuronios-das-coisas-boas-e-das-coisas-mas/

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Projects

As Leader

Projects

As Member

Brainstem orchestration of cue-reward associations

The brain constantly integrates new sensory information, and associates environmental cues to outcomes, adjusting behavior to maximize reward and minimize unpleasant consequences. This process is critical for survival, and its dysregulation is a hallmark of…

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