Ana Mendes-Frias

  • Intestinal Inflammation
  • Ulcerative colitis
  • Immunology
  • Branched-chain aminoacids
  • Supplementation
  • Infection

Ana Mendes Frias (AMF) is a PhD student at Life and Health Sciences Research Institute (ICVS). She completed a degree in Biochemistry at the University of Coimbra (2014). During this period, AMF worked as a research trainee in IBILI (Coimbra) under the supervision of Margarida Abrantes. In this internship she learned the basis of cell culture and drug screening in the context of cancer research. Afterwards, she obtained a master’s degree in clinical Analysis (2016) at the University of Coimbra. During her master internship, AMF joined Laboratório S. José (Coimbra) and worked under the supervision of Paulo João Soares. In 2017 she joined a pharmaceutical industry (Labialfarma, Viseu), where she was part of the quality control team. In 2018 she enrolled in the PhD in Health Sciences at University of Minho and, since then, she is working under the supervision of Ricardo Silvestre. Her PhD thesis aims to unravel the dynamic effect branched-chain amino acids in gut homeostasis and inflammation. Besides this, she collaborated in other projects in immunology and infection that allowed her to publish several articles in scientific peer-reviewed international journals.

Scientific Highlights

“- Mendes-Frias A, Gallo V, Iacobelli V, Gentile R, Antonini G, Silvestre R, Iacobelli S. Galectin-3 binding protein stimulated IL-6 expression is impeded by antibody intervention in SARS-CoV-2 susceptible cell lines. Scientific Reports, 2022

– André S, Azarias da Silva M, Picard M, Alleaume-Buteau A, Kundura L, Cezar R, Soudaramourty C, André SC, Mendes-Frias A, Carvalho A, Capela C, Pedrosa J, Gil Castro A, Loubet P, – Sotto A, Muller L, Lefrant JY, Roger C, Claret PG, Duvnjak S, Tran TA, Zghidi-Abouzid O, Nioche P, Silvestre R, Corbeau P, Mammano F, Estaquier J. Low quantity and quality of anti-spike humoral response is linked to CD4 T-cell apoptosis in COVID-19 patients. Cell Death Dis. 2022 Aug 27;13(8):741.

-André, S., Picard, M., Cezar, R., Roux-Dalvai, F., Alleaume-Butaux, A., Soundaramourty, C., Cruz, A. S., Mendes-Frias, A., Gotti, C., Leclercq, M., Nicolas, A., Tauzin, A., Carvalho, A., Capela, C., Pedrosa, J., Castro, A. G., Kundura, L., Loubet, P., Sotto, A., Muller, L., … Estaquier, J. (2022). T cell apoptosis characterizes severe Covid-19 disease. Cell death and differentiation, 1–14.

-Santa Cruz, A., Mendes-Frias, A., Oliveira, A. I., Dias, L., Matos, A. R., Carvalho, A., Capela, C., Pedrosa, J., Castro, A. G., & Silvestre, R. (2021). Interleukin-6 Is a Biomarker for the Development of Fatal Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia. Frontiers in immunology, 12, 613422.

-Mendes-Frias, A., Santos-Lima, B., Furtado, D., Ruperez, F. J., Assunção, N. A., Matias, M. J., Gomes, V., Gaifem, J., Barbas, C., Castro, A. G., Capela, C., & Silvestre, R. (2020). Dysregulation of glycerophospholipid metabolism during Behçet’s disease contributes to a pro-inflammatory phenotype of circulating monocytes. Journal of translational autoimmunity, 3, 100056.


Gut microbiota, metabolites and host immunity

The intestinal epithelial barrier (EB) represents the largest interface between the internal organs and the environment. The precise regulation of the intestinal EB allows the maintenance of mucosal immune homeostasis and prevents the onset of uncontrolled inflammation.

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