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Immunobiology of Inflammatory and Infectious Diseases
Team Members
![agostinho_carvalho](https://icvs.uminho.pt/wp-content/uploads/2023/01/agostinho_carvalho.jpg)
![cristina_cunha](https://icvs.uminho.pt/wp-content/uploads/2023/01/cristina_cunha.jpg)
Cristina Cunha
![eg¡dio_torrado](https://icvs.uminho.pt/wp-content/uploads/2023/01/eg¡dio_torrado.jpg)
Egídio Torrado
![ricardo_silvestre](https://icvs.uminho.pt/wp-content/uploads/2023/01/ricardo_silvestre.jpg)
Ricardo Silvestre
![gil_castro](https://icvs.uminho.pt/wp-content/uploads/2023/01/gil_castro.jpg)
António G. Castro
![fernando_rodrigues](https://icvs.uminho.pt/wp-content/uploads/2023/01/fernando_rodrigues.jpg)
Fernando Rodrigues
![diana_ribeiro_thumb](https://icvs.uminho.pt/wp-content/uploads/2023/09/diana_ribeiro_thumb.jpg)
Diana Ribeiro
![relber_goncales](https://icvs.uminho.pt/wp-content/uploads/2023/01/relber_goncales.jpg)
Relber A. Gonçales
![rita_gomes_thumb](https://icvs.uminho.pt/wp-content/uploads/2022/11/rita_gomes_thumb.jpg)
Rita Silva-Gomes
![samuel_goncalves](https://icvs.uminho.pt/wp-content/uploads/2023/01/samuel_goncalves.jpg)
Samuel M Gonçalves
![sandra_costa](https://icvs.uminho.pt/wp-content/uploads/2023/01/sandra_costa.jpg)
Sandra Costa
![ana_frias](https://icvs.uminho.pt/wp-content/uploads/2023/01/ana_frias.jpg)
Ana Mendes-Frias
![andré_santa_cruz_thumb](https://icvs.uminho.pt/wp-content/uploads/2023/02/andre_santa_cruz_thumb.jpg)
André Santa Cruz
![caroline_pereira](https://icvs.uminho.pt/wp-content/uploads/2023/01/caroline_pereira.jpg)
Caroline Borges-Pereira
![catarina_matos_thumb](https://icvs.uminho.pt/wp-content/uploads/2022/11/catarina_matos_thumb.jpg)
Catarina Barbosa-Matos
![consuelo_micheli](https://icvs.uminho.pt/wp-content/uploads/2023/01/consuelo_micheli.jpg)
Consuelo Micheli
![ines_caldeira](https://icvs.uminho.pt/wp-content/uploads/2023/01/ines_caldeira.jpg)
Inês Caldeira
![maria_inês_pereira_thumb](https://icvs.uminho.pt/wp-content/uploads/2023/09/maria_ines_pereira_thumb.png)
Inês Pereira
![marcela_oliveira_thumb](https://icvs.uminho.pt/wp-content/uploads/2023/02/marcela_oliveira_thumb.jpg)
Marcela Oliveira
![marta_araujo](https://icvs.uminho.pt/wp-content/uploads/2023/01/marta_araujo.jpg)
Marta Araújo
![raquel_fernandes](https://icvs.uminho.pt/wp-content/uploads/2023/01/raquel_fernandes.jpg)
Raquel Fernandes
![sonia_carvalho](https://icvs.uminho.pt/wp-content/uploads/2023/01/sonia_carvalho.jpg)
Sónia Barros-Carvalho
![ana_baptista](https://icvs.uminho.pt/wp-content/uploads/2023/01/ana_baptista.jpg)
Ana Baptista
![barbara_mota_thumb](https://icvs.uminho.pt/wp-content/uploads/2024/01/barbara_mota_thumb.jpg)
Bárbara Mota
![maria_catarina_vieira_thumb](https://icvs.uminho.pt/wp-content/uploads/2022/11/maria_catarina_vieira_thumb.jpg)
Maria Catarina Vieira
![tiago_cardoso_thumb](https://icvs.uminho.pt/wp-content/uploads/2023/10/tiago_cardoso_thumb.jpg)
Tiago Cardoso
Team Members
![](https://icvs.uminho.pt/wp-content/uploads/2023/01/agostinho_carvalho.jpg)
agostinho carvalho
Principal Investigator
Team Coordinator
![](https://icvs.uminho.pt/wp-content/uploads/2023/01/eg¡dio_torrado.jpg)
egídio torrado
Principal Investigator
![](https://icvs.uminho.pt/wp-content/uploads/2023/01/ricardo_silvestre.jpg)
ricardo silvestre
Principal Investigator
![](https://icvs.uminho.pt/wp-content/uploads/2023/01/gil_castro.jpg)
António G. Castro
Senior Researcher
![](https://icvs.uminho.pt/wp-content/uploads/2023/01/fernando_rodrigues.jpg)
fernando rodrigues
Senior Researcher
![](https://icvs.uminho.pt/wp-content/uploads/2023/01/cristina_cunha.jpg)
cristina cunha
Assistant Researcher
![](https://icvs.uminho.pt/wp-content/uploads/2023/02/maria_joao_peixoto_thumb.jpg)
Maria João Peixoto
Postdoctoral Researcher
![](https://icvs.uminho.pt/wp-content/uploads/2023/01/relber_goncales.jpg)
relber gonçales
Postdoctoral Researcher
![](https://icvs.uminho.pt/wp-content/uploads/2023/02/rita_gomes_thumb.jpg)
Rita Silva-Gomes
Postdoctoral Researcher
![](https://icvs.uminho.pt/wp-content/uploads/2023/01/sandra_costa.jpg)
sandra costa
Affiliated Researcher
![](https://icvs.uminho.pt/wp-content/uploads/2023/01/ana_frias.jpg)
ana mendes-frias
PhD Student
![](https://icvs.uminho.pt/wp-content/uploads/2023/02/andre_santa_cruz_thumb.jpg)
André Santa Cruz
PhD Student
![](https://icvs.uminho.pt/wp-content/uploads/2023/01/caroline_pereira.jpg)
Caroline Borges-Pereira
PhD Student
![](https://icvs.uminho.pt/wp-content/uploads/2022/11/Group-2248.png)
Catarina Barbosa-Matos
PhD Student
![](https://icvs.uminho.pt/wp-content/uploads/2023/01/claudio_oliveira.jpg)
cláudio oliveira
PhD Student
![](https://icvs.uminho.pt/wp-content/uploads/2023/01/consuelo_micheli.jpg)
consuelo micheli
PhD Student
![](https://icvs.uminho.pt/wp-content/uploads/2023/01/daniela_antunes.jpg)
daniela antunes
PhD Student
![](https://icvs.uminho.pt/wp-content/uploads/2023/01/marta_araujo.jpg)
marta araújo
PhD Student
![](https://icvs.uminho.pt/wp-content/uploads/2023/01/raquel_fernandes.jpg)
raquel fernandes
PhD Student
![](https://icvs.uminho.pt/wp-content/uploads/2023/01/samuel_goncalves.jpg)
samuel gonçalves
PhD Student
![](https://icvs.uminho.pt/wp-content/uploads/2023/01/adrian_barnutiu.jpg)
adrian barnutiu
MSc Student
![](https://icvs.uminho.pt/wp-content/uploads/2023/01/ana_baptista.jpg)
ana baptista
MSc Student
![](https://icvs.uminho.pt/wp-content/uploads/2022/11/maria_catarina_vieira_thumb.jpg)
Maria Catarina Vieira
MSc Student
![](https://icvs.uminho.pt/wp-content/uploads/2023/01/sonia_carvalho.jpg)
sónia carvalho
MSc Student
Projects
- Agostinho Carvalho
- Genetic analysis of molecular and functional traits in immune cells, such as gene and protein expression and effector functions, offers a promising strategy for investigating phenotypic variation and dissecting the molecular mechanisms underlying propensity to infection.
- Ricardo Silvestre
- The intestinal epithelial barrier (EB) represents the largest interface between the internal organs and the environment. The precise regulation of the intestinal EB allows the maintenance of mucosal immune homeostasis and prevents the onset of uncontrolled inflammation.
- Cristina Cunha
- The reprogramming of cellular metabolism is a fundamental mechanism whereby immune cells respond to infection. The sensing of microbial ligands by myeloid cells promotes dynamic changes in host cell metabolism to deliver a rapid source of energy to support…
- Egídio Torrado
- The protective immune response to Mycobacterium tuberculosis requires tight regulation in order to prevent the development of pathological consequences to the host. Our lab is focused in defining the mechanisms that regulate the balance between protection…
- Ricardo Silvestre
- Innate immune cells tightly coordinate their metabolic programs to support a proper immunological function. As such, perturbed metabolic fluxes imply decisive effects on immune cell activation eventuating in their ability to control a pathogen and the disease inflicted by it.
- Sandra Costa
- Acute lung injury and idiopathic pulmonary fibrosis are severe lung diseases causing irreversible lung damage with a high mortality rate and ineffective treatment approaches. Excessive inflammatory response, abnormal self-repair, and fibrosis development…
- Cristina Cunha
- Recent studies have successfully implicated several factors in the susceptibility to fungal infection, but have provided little insight into the nature of the underlying biological mechanisms. We propose a multiomics approach to link deep clinical phenotyping…
- Agostinho Carvalho
- Sarcoidosis is a multisystemic granulomatous disease of unknown aetiology with lung involvement in most cases. The pathological hallmark of sarcoidosis is the formation of non-necrotizing granulomas incited by the accumulation of activated macrophages…
Selected Research Outputs
Hérivaux A, Willis JR, Mercier T, Lagrou K, Gonçalves SM, Gonçales RA, Maertens J, Carvalho A, Gabaldón T, Cunha C. “Lung microbiota predict invasive pulmonary aspergillosis and its outcome in immunocompromised patients”. Thorax. 2022; epub ahead of print
Ferreira C, Estaquier J, Silvestre R. Immune-metabolic interactions between Leishmania and macrophage host. Curr. Opin. Microbiol. 2021 63:231-237.
Ferreira CM, Barbosa AM, Barreira-Silva P, Silvestre R, Cunha C, Carvalho A, Rodrigues F, Correia-Neves M, Castro AG, Torrado E. Early IL-10 promotes vasculature-associated CD4+ T cells unable to control Mycobacterium tuberculosis infection. JCI Insight. 2021 Nov 8;6(21):e150060. doi: 10.1172/jci.insight.150060.
Gonçalves SM, Antunes D, Leite L, Mercier T, Horst RT, Vieira J, Espada E, Pinho Vaz C, Branca R, Campilho F, Freitas F, Ligeiro D, Marques A, van de Veerdonk FL, Joosten LAB, Lagrou K, Maertens J, Netea MG, Lacerda JF, Campos A Jr, Cunha C, Carvalho A. “Genetic variation in PFKFB3 impairs antifungal immunometabolic responses and predisposes to invasive pulmonary aspergillosis”. mBio. 2021; 12(3):e0036921
Gonçales RA, Ricci-Azevedo R, Vieira VCS, Fernandes FF, Thomaz SMO, Carvalho A, Vendruscolo PE, Cunha C, Roque-Barreira MC, Rodrigues F. “Paracoccin overexpression in Paracoccidioides brasiliensis enhances fungal virulence by remodeling chitin properties of the cell wall”. J Infect Dis. 2021; 224(1):164-174
Santa Cruz A, Mendes-Frias A, Oliveira AI, Dias L, Matos AR, Carvalho A, Capela C, Pedrosa J, Castro AG, Silvestre R. "Interleukin-6 Is a Biomarker for the Development of Fatal Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia". Front Immunol. 2021 Feb 18;12:613422
Mesquita I, Ferreira C, Moreira D, Kluck GEG, Barbosa AM, Torrado E, Dinis-Oliveira RJ, Gonçalves LG, Beauparlant CJ, Droit A, Berod L, Sparwasser T, Bodhale N, Saha B, Rodrigues F, Cunha C, Carvalho A, Castro AG, Estaquier J, Silvestre R. The Absence of HIF-1α Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis. Cell Rep. 2020 Mar 24;30(12):4052-4064.e7
Gonçalves SM, Duarte-Oliveira C, Campos CF, Aimanianda V, Ter Horst R, Leite L, Mercier T, Pereira P, Fernández-García M, Antunes D, Rodrigues CS, Barbosa-Matos C, Gaifem J, Mesquita I, Marques A, Osório NS, Torrado E, Rodrigues F, Costa S, Joosten LA, Lagrou K, Maertens J, Lacerda JF, Campos A Jr, Brown GD, Brakhage AA, Barbas C, Silvestre R, van de Veerdonk FL, Chamilos G, Netea MG, Latgé JP, Cunha C, Carvalho A. “Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity”. Nat Commun. 2020; 11(1):2282
Resende M, Ferreira CM, Barbosa AM, Cardoso MS, Sousa J, Saraiva M, Castro AG, Appelberg R, Torrado E. Myeloid HIF-1α regulates pulmonary inflammation during experimental Mycobacterium tuberculosis infection. Immunology. 2020 Jan;159(1):121-129. doi: 10.1111/imm.13131. Epub 2019 Nov 10.
Campos CF, Leite L, Pereira P, Pinho Vaz C, Branca R, Campilho F, Freitas F, Ligeiro D, Marques A, Torrado E, Silvestre R, Lacerda JF, Campos A Jr, Cunha C, Carvalho A. “PTX3 polymorphisms influence cytomegalovirus reactivation after stem-cell transplantation”. Front Immunol. 2019; 10:88
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Contact us
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Fax: +351 253 604 809
Email: icvs.sec@med.uminho.pt
Address
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
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Portugal
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Copyright ©2022 ICVS. All Rights Reserved
Address
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal
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Copyright ©2022 ICVS. All Rights Reserved
Address
Life and Health Sciences
Research Institute (ICVS)
School of Medicine,
University of Minho,
Campus de Gualtar
4710-057 Braga
Portugal