Sónia Barros-Carvalho

  • Leishmania
  • Immunometabolism
  • Macrophage
  • Glycolysis
  • Immunotherapeutic
  • Infectious Diseases

Sónia Barros Carvalho (SBC) is currently a master’s student in Health Sciences at the School of Medicine, University of Minho. In July 2020, she graduated in Biochemistry at the University of Porto, a joined course by the Faculty of Sciences (FCUP) and the School of Medicine and Biomedical Sciences (ICBAS). During her degree, she did a 6-month extra-curricular internship (FCUP’s Extracurricular Internship Program – PEEC) in Paula Gameiro’s (PhD) group, where SBC worked in the study of drug affinity for biological membrane mimetic systems and its implication in fighting bacterial resistance. A year later, she joined the Microbes & Cancer Group at i3S – Institute for Research and Innovation in Health, where as a research trainee under the guidance of Céu Figueiredo (PhD) and Joana Pereira-Marques (PhD), SBC did her degree internship in the establishment of methods for the quantification of microorganisms of importance in the human microbiome. As a member of NEBQUP – Núcleo de Estudantes de Bioquímica do Porto, she collaborated in the organization of scientific dissemination events related to the biochemistry and life sciences field (2017-2020), having also mentored younger biochemistry students within the FCUP mentoring program (2019/2020).
Currently, she is developing her master’s thesis in the i3D – Immunobiology of Inflammatory and Infectious Diseases group, at ICVS – Life and Health Sciences Research Institute. Supervised by Ricardo Silvestre (PhD), SBC has been working on the pharmacological modulation of glycolysis, studying its importance in the context of visceral leishmaniasis infection, with the aim of its possible application as an immunotherapeutic adjuvant.

Scientific Highlights

“Targeting glycolysis in Leishmania therapy”, Sónia Barros-Carvalho, Ricardo Silvestre – Poster presentation at the XLVII Annual Meeting of the Portuguese Society for Immunology (April 2022)


Immunometabolic networks on Leishmania infection

Innate immune cells tightly coordinate their metabolic programs to support a proper immunological function. As such, perturbed metabolic fluxes imply decisive effects on immune cell activation eventuating in their ability to control a pathogen and the disease inflicted by it.

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