Inês Caldeira

  • Fungal infection
  • functional genomics
  • antifungal immunity
  • immunometabolism
  • personalized medicine

Inês Caldeira obtained her B.Sc. in Biochemistry in 2019 from the Faculty of Sciences, University of Porto. Later in 2022, Inês was conferred an M.Sc. degree in Applied Biochemistry in Biomedicine by the University of Minho. Her thesis research at the Life and Health Sciences Research Institute (ICVS) focused on studying Vitamin D signaling pathway involvement in normal/abnormal embryonic lung development, under the supervision of Dr. Rute Moura. In 2024, Inês joined the Applied Health Sciences PhD program at the School of Medicine at the University of Minho, where she is currently developing her PhD thesis under the supervision of Dr. Cristina Cunha and Dr. Agostinho Carvalho. Her Ph.D. thesis focuses mainly on exploring the influence of specific host genetic backgrounds on the activation of immunity and inflammation and how that may render individuals susceptible to fungal infection. She is currently dissecting how Interleukine-37 (IL-37) regulates the metabolic reprogramming of myeloid cells upon fungal infection and predisposes them to invasive pulmonary aspergillosis (IPA).

Inês Caldeira

  • Fungal infection
  • functional genomics
  • antifungal immunity
  • immunometabolism
  • personalized medicine

Inês Caldeira obtained her B.Sc. in Biochemistry in 2019 from the Faculty of Sciences, University of Porto. Later in 2022, Inês was conferred an M.Sc. degree in Applied Biochemistry in Biomedicine by the University of Minho. Her thesis research at the Life and Health Sciences Research Institute (ICVS) focused on studying Vitamin D signaling pathway involvement in normal/abnormal embryonic lung development, under the supervision of Dr. Rute Moura. In 2024, Inês joined the Applied Health Sciences PhD program at the School of Medicine at the University of Minho, where she is currently developing her PhD thesis under the supervision of Dr. Cristina Cunha and Dr. Agostinho Carvalho. Her Ph.D. thesis focuses mainly on exploring the influence of specific host genetic backgrounds on the activation of immunity and inflammation and how that may render individuals susceptible to fungal infection. She is currently dissecting how Interleukine-37 (IL-37) regulates the metabolic reprogramming of myeloid cells upon fungal infection and predisposes them to invasive pulmonary aspergillosis (IPA).

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Projects

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Projects

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Functional genomics of fungal disease

Genetic analysis of molecular and functional traits in immune cells, such as gene and protein expression and effector functions, offers a promising strategy for investigating phenotypic variation and dissecting the molecular mechanisms underlying propensity to infection.

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Host-fungus interaction and disease pathogenesis

The reprogramming of cellular metabolism is a fundamental mechanism whereby immune cells respond to infection. The sensing of microbial ligands by myeloid cells promotes dynamic changes in host cell metabolism to deliver a rapid source of energy to support…

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