André Santa Cruz

  • Internal Medicine
  • Infectious Diseases
  • pathophysiology
  • COVID-19
  • Inflammation
  • Immune response

André Santa Cruz great interest in the research field of infectious diseases, specifically the interaction between the host and the infectious agent, aroused from his clinical practice a few years ago. By connecting clinical and laboratory research, he is aiming at identifying and understanding the basic molecular and cellular mechanisms that correlate with disease severity,
response to treatment and patients’ outcome. Current COVID-19 pandemic highlighted the need of a greater comprehension of the pathophysiological processes involved in viral infection, concerning inflammatory and immune responses. This knowledge may be used to guide clinical practice in the near future and to develop new therapeutic targets.

Scientific Highlights

André S, Azarias da Silva M, Picard M, Alleaume-Buteau A, Kundura L, Cezar R, Soudaramourty C, André SC, Mendes-Frias A, Carvalho A, Capela C, Pedrosa J, Gil Castro A, Loubet P, – Sotto A, Muller L, Lefrant JY, Roger C, Claret PG, Duvnjak S, Tran TA, Zghidi-Abouzid O, Nioche P, Silvestre R, Corbeau P, Mammano F, Estaquier J. Low quantity and quality of anti-spike humoral response is linked to CD4 T-cell apoptosis in COVID-19 patients. Cell Death Dis. 2022 Aug 27;13(8):741.

-André, S., Picard, M., Cezar, R., Roux-Dalvai, F., Alleaume-Butaux, A., Soundaramourty, C., Cruz, A. S., Mendes-Frias, A., Gotti, C., Leclercq, M., Nicolas, A., Tauzin, A., Carvalho, A., Capela, C., Pedrosa, J., Castro, A. G., Kundura, L., Loubet, P., Sotto, A., Muller, L., … Estaquier, J. (2022). T cell apoptosis characterizes severe Covid-19 disease. Cell death and differentiation, 1–14.

– Santa Cruz A, Mendes-Frias A, Oliveira AI, Dias L, Matos AR, Carvalho A, Capela C, Pedrosa J, Castro AG and Silvestre R, Interleukin-6 Is a Biomarker for the Development of Fatal Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia. Front. Immunol. 2021, 12:613422.

– Pires, O.; Oliveira, A.A.; Moreira, P.; Santa Cruz, A.; Carvalho, A.; Alves, J.; Knowledge and Attitudes Towards COVID-19: A Cross- – sectional Study in Portugal, Acta Med Port, Vol 34, No 5 (2021).

– Mendes, M; Oliveira, A.A; Pires, O.; Branca, F.; Beirão, M; Santa Cruz, A.; Carvalho, A.; Alves, J.; Sampling Methods and Risk Stratification Regarding Environmental Contamination by SARS-CoV-2, Acta Med Port 2021 34(AOP)
– Sousa R, Costa P, Cerqueira J, Pêgo JM, Santa Cruz A, Oliveira e Silva A, Sousa N, Pereira VH, Translation, adaptation and validation of the Mini-Clinical Evaluation Exercise to the EU-Portuguese language, FEM. Revista de la Fundación Educación Médica 2020;23(4): 179-192
– Caetano AC, Santa-Cruz A, Rolanda C. Digital Rectal Examination and Balloon Expulsion Test in the Study of Defecatory Disorders: Are They Suitable as Screening or Excluding Tests? Can J Gastroenterol Hepatol. 2016; 2016:8654314; doi: 10.1155/2016/8654314

– Caetano AC, Dias S, Santa-Cruz A, Rolanda C, Renzi Score for obstructed defecation syndrome – validation of the portuguese version according to the Cosmin Checklist, Arquivos de Gastroenterologia, 55 (1), 55-60; 2018, doi: 10.1590/s0004-2803.201800000-11


– Inês Burmester, Rui M. Domingues, Eduardo Ferreira Freitas, Maria João Regadas, André Santa Cruz, Clinical significance of cerebrospinal fluid Herpesvirus 6 positivity – A case series study, Archives of Clinical and Medical Case Reports 4 (2020): 1130-1139. DOI: 10.26502/acmcr.96550307

– Invited speaker at 26th National Congress of Internal Medicine / VII Iberian Congress of Internal Medicine, on the subject: “Pharmacological strategies for COVID-19”, August 2020