Samuel M Gonçalves

  • Immunology
  • Infectious Diseases
  • Fungal infection
  • Immunometabolism
  • Personalized Medicine

Samuel Gonçalves graduated in 2015 in Biology by the University of Minho and received a Master degree in Health Sciences from the same University in 2017. During his academic training, he was actively involved in the field of fungal immunology an immunogenetics. He is currently a PhD student under the supervision of Dr. Agostinho Carvalho at the Immunobiology of Inflammatory and Infectious diseases Research Group in Life and Health Sciences Research Institute (ICVS) of the University of Minho. His current research interests regard how human metabolism, namely the metabolism of macrophages, can modulate immune responses in patients at higher risk of invasive fungal disease.


Functional genomics of fungal disease

Genetic analysis of molecular and functional traits in immune cells, such as gene and protein expression and effector functions, offers a promising strategy for investigating phenotypic variation and dissecting the molecular mechanisms underlying propensity to infection.

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Host-fungus interaction and disease pathogenesis

The reprogramming of cellular metabolism is a fundamental mechanism whereby immune cells respond to infection. The sensing of microbial ligands by myeloid cells promotes dynamic changes in host cell metabolism to deliver a rapid source of energy to support…

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Lung microbiome and mucosal immunity

Recent studies have successfully implicated several factors in the susceptibility to fungal infection, but have provided little insight into the nature of the underlying biological mechanisms. We propose a multiomics approach to link deep clinical phenotyping…

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