Egídio Torrado

  • Tuberculosis
  • Immunopathology
  • Aquired immunity
  • Vaccination
  • Immunotherapy

Egídio Torrado received a PhD in health sciences in 2007 awarded by the University of Minho (Braga, Portugal) on the mechanisms of protection and pathogenesis of Mycobacterium ulcerans infection. From 2008-2013, he was a postdoctoral fellow at the Trudeau Institute (Saranac Lake, NY, USA) where he studied the immunological mechanisms that regulate the expression and maintenance of CD4 T cell responses in the Mycobacterium tuberculosis infected lungs. In 2014, Egídio Torrado returned to Portugal to establish his lab at the Life and Health Sciences Research Institute (ICVS). Since 2015, Egídio Torrado is a FCT assistant researcher. His current research activities aim to define further the mechanisms that regulate immune responses in the lung, with the overarching goal of learning novel ways to instruct immunity to improve vaccination and develop novel immunotherapies.

Scientific Highlights

1- Ferreira CM, Micheli C, Barreira-Silva P, Barbosa AM, Resende M, Vilanova M, Silvestre R, Cunha C, Carvalho A, Rodrigues F, Correia-Neves M, Castro AG, Torrado E. (2022). IL-10 overexpression after BCG vaccination does not impair control of Mycobacterium tuberculosis infection. Front Immunol. 13: 946181.

2- Ferreira CM, Barbosa AM, Barreira-Silva P, Silvestre R, Cunha C, Carvalho A, Rodrigues F, Correia-Neves M, Castro AG, Torrado E. (2021). Early IL-10 promotes vasculature-associated CD4+ T cells unable to control Mycobacterium tuberculosis infection. JCI Insight. 6: e150060.

3- Martínez-Pérez A, Igea A, Estévez O, Ferreira CM, Torrado E, Castro AG, Fernández C, Spetz AL, Adam L, López González M, Singh M, Reljic R, González-Fernández Á. (2021). Changes in the immune phenotype and gene expression profile driven by a novel tuberculosis nanovaccine: short and long-term post-immunization. Front Immunol. 11: 589863.

4- Barbosa AM, Martinho O, Nogueira R, Campos J, Lobo L, Pinto H, Longatto-Filho A, Castro AG, Martins SF, Torrado E. (2021). Increased CD3+, CD8+, or FoxP3+ T lymphocyte infiltrations are associated with the pathogenesis of colorectal cancer but not with the overall survival of patients. Biology (Basel). 10: 808.

5- Barbosa AM, Gomes-Gonçalves A, Castro AG, Torrado E. (2021). Immune system efficiency in cancer and the microbiota influence. Pathobiology. 15: 1-17.

6- Resende M, Ferreira CM, Barbosa AM, Cardoso MS, Sousa J, Saraiva M, Castro AG, Appelberg R, Torrado E. (2020). Myeloid HIF-1α regulates pulmonary inflammation during experimental Mycobacterium tuberculosis infection. Immunology. 159: 121-129.

7- Fraga AG, Barbosa AM, Ferreira CM, Fevereiro J, Pedrosa J, Torrado E. (2018). Immune-evasion strategies of mycobacteria and their implications for the protective immune response. Curr Issues Mol Biol 25:169-198.

8- Torrado E, Fountain JJ, Liao M, Tighe M, Reiley WW, Lai RPJ, Meintjes G, Pearl JE, Chen X, Zak DE, Thompson EG, Aderem A, Ghilardi N, Solache A, McKinstry K, Strutt T, Wilkinson RJ, Swain S, Cooper AM. (2015). Interleukin 27R regulates CD4+ T cell phenotype and impacts protective immunity during Mycobacterium tuberculosis infection. J Exp Med. 212: 1449-63.


Immunobiology of tuberculosis

The protective immune response to Mycobacterium tuberculosis requires tight regulation in order to prevent the development of pathological consequences to the host. Our lab is focused in defining the mechanisms that regulate the balance between protection…

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