António G. Castro

  • Tuberculosis
  • Immunopathology
  • Aquired immunity
  • Vaccination
  • Immunotherapy

Gil Castro began his scientific career at the Center for Experimental Cytology (University of Porto, Portugal) where he identified the role of IL-12 in the differentiation of Th1 type of responses, following Mycobacterium avium infection. He then moved to the DNAX Research Institute (Palo Alto, CA, USA) as a postdoctoral fellow to extend his investigation in markers of Th1/Th2 cells and the factors that regulate their differentiation. In 1998 Gil Castro returned to Portugal, to the Gulbenkian Institute for Science (Lisbon, Portugal), where he acquired knowledge and skills in molecular biology and made two lines of transgenic mice that allowed for the controlled expression of IL-10 or IL-4. In 2002, Gil Castro moved to the Life and Health Sciences Research Institute (University of Minho, Braga, Portugal) to focus his investigation on the immunological mechanism underlying protective/pathologic immune responses to Mycobacterium tuberculosis. His work contributed to elucidate the role of Interferon-gamma as a regulator of Th17 responses and the pathological consequences of the IL-23/IL-17 axis following BCG revaccination.


Immunobiology of tuberculosis

The protective immune response to Mycobacterium tuberculosis requires tight regulation in order to prevent the development of pathological consequences to the host. Our lab is focused in defining the mechanisms that regulate the balance between protection…

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