Jennifer Scott

  • Metabolism
  • Fungal infection
  • Drug discovery
  • Aspergillus fumigatus
  • Pseudomonas aeruginosa
  • Polymicrobial infections

Jennifer is a postdoctoral researcher working in the group of Dr. Cristina Cunha at the Life and Health Sciences Research Institute (ICVS), University of Minho. Her work focuses on fungal pathogenesis and host-fungus-microbiota interactions, aiming to improve the understanding and treatment of life-threatening mycoses. She earned her BSc (Hons) in Biology from the University of Bath, England (2014). Her studies included a year-long research placement under the supervision of Professor Scott Moye-Rowley at the University of Iowa, USA, where she investigated transcriptional events driving fungal multi-drug resistance. In 2016 Jennifer joined the group of Dr. Jorge Amich at the University of Manchester, England, as a Research Technician before completing her PhD (2023) in the same group. Her research explored Aspergillus fumigatus virulence, particularly the role of sulfur metabolism. This included characterizing the metabolic basis of methionine synthase conditional essentiality and defining the metabolic pathway responsible for a volatile mediated synergism that increases pathogenicity in Pseudomonas aeruginosa – A. fumigatus co-infection. She also optimized a regulatable expression system for validation of drug targets in models of established invasive pulmonary aspergillosis and contributed to the observation, description, and initial characterization of A. fumigatus persistence in supra-MIC voriconazole concentrations. Jennifer’s current work at ICVS utilizes a multi-omics approach to explore microbiota dynamics throughout infection. Connecting clinical phenotyping with molecular and genetic signatures of the host-fungus-microbiota interaction, this research seeks to inform personalized diagnosis, prognosis, and treatment of fungal diseases.

Jennifer Scott

  • Metabolism
  • Fungal infection
  • Drug discovery
  • Aspergillus fumigatus
  • Pseudomonas aeruginosa
  • Polymicrobial infections

Jennifer is a postdoctoral researcher working in the group of Dr. Cristina Cunha at the Life and Health Sciences Research Institute (ICVS), University of Minho. Her work focuses on fungal pathogenesis and host-fungus-microbiota interactions, aiming to improve the understanding and treatment of life-threatening mycoses. She earned her BSc (Hons) in Biology from the University of Bath, England (2014). Her studies included a year-long research placement under the supervision of Professor Scott Moye-Rowley at the University of Iowa, USA, where she investigated transcriptional events driving fungal multi-drug resistance. In 2016 Jennifer joined the group of Dr. Jorge Amich at the University of Manchester, England, as a Research Technician before completing her PhD (2023) in the same group. Her research explored Aspergillus fumigatus virulence, particularly the role of sulfur metabolism. This included characterizing the metabolic basis of methionine synthase conditional essentiality and defining the metabolic pathway responsible for a volatile mediated synergism that increases pathogenicity in Pseudomonas aeruginosa – A. fumigatus co-infection. She also optimized a regulatable expression system for validation of drug targets in models of established invasive pulmonary aspergillosis and contributed to the observation, description, and initial characterization of A. fumigatus persistence in supra-MIC voriconazole concentrations. Jennifer’s current work at ICVS utilizes a multi-omics approach to explore microbiota dynamics throughout infection. Connecting clinical phenotyping with molecular and genetic signatures of the host-fungus-microbiota interaction, this research seeks to inform personalized diagnosis, prognosis, and treatment of fungal diseases.

Scientific Highlights

Scott J*, Valero C*, Mato-López A, Donaldson I, Roldán A, et al. 2023. Aspergillus fumigatus can display persistence to the fungicidal drug voriconazole. Microbiology Spectrum 11: e04770-22 https://doi.org/10.1128/spectrum.04770-22. *joint first author

Sueiro-Olivares M, Scott J, Gago S, Petrovic D, Kouroussis E, et al. 2021. Fungal and host protein persulfidation are functionally correlated and modulate both virulence and antifungal response. PLOS Biology 19: e3001247 https://doi.org/10.1371/journal.pbio.3001247.

Scott J and Amich J. 2021. Primary Metabolism of Human Pathogenic Fungi, Importance for Virulence and Potential for Drug Development. Reference Module in Biomedical Sciences 1:377-407 https://doi.org/10.1016/B978-0-12-818731-9.00059-8.

Scott J, Sueiro-Olivares M, Thornton BP, Owens RA, Muhamadali H, et al. 2020. Targeting Methionine Synthase in a Fungal Pathogen Causes a Metabolic Imbalance That Impacts Cell Energetics, Growth, and Virulence. mBio 11: e01985-20 https://doi.org/ 10.1128/mBio.01985-20.

Scott J, Sueiro-Olivares M, Thornton BP, Owens RA, Muhamadali H, et al. 2019. Pseudomonas aeruginosa-Derived Volatile Sulfur Compounds Promote Distal Aspergillus fumigatus Growth and a Synergistic Pathogen-Pathogen Interaction That Increases Pathogenicity in Co-infection. Frontiers in Microbiology 10: 2311 https://doi.org/10.3389/fmicb.2019.02311.

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Projects

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Projects

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Host-fungus interaction and disease pathogenesis

The reprogramming of cellular metabolism is a fundamental mechanism whereby immune cells respond to infection. The sensing of microbial ligands by myeloid cells promotes dynamic changes in host cell metabolism to deliver a rapid source of energy to support…

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Lung microbiome and mucosal immunity

Recent studies have successfully implicated several factors in the susceptibility to fungal infection, but have provided little insight into the nature of the underlying biological mechanisms. We propose a multiomics approach to link deep clinical phenotyping…

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