Agostinho Carvalho

  • Fungal infection
  • functional genomics
  • antifungal immunity
  • immunometabolism
  • inflammation

Agostinho Carvalho graduated in 2003 in Biology from the University of Minho and received a PhD in Health Sciences from the same University in 2008. Between 2009 and 2012, he developed postdoctoral studies on the genetic basis of susceptibility to fungal infection at the Life and Health Sciences Research Institute (ICVS) of the University of Minho, and the University of Perugia, Italy. In 2012, he became an Assistant Researcher at the Department of Experimental Medicine of the University of Perugia, where he further developed his interests in fungal immunology and immunogenetics until 2014.
Later that year, he became an Assistant Researcher (FCT Investigator) and returned to ICVS, where he consolidated his research team. Since 2019, he is a Principal Investigator at ICVS (tenured since 2021). His current research activity is focused on the elucidation of the effects of interindividual genetic variation on molecular and cellular processes of immunity and inflammation, and the translation of this information into new and personalized approaches for the prognosis, diagnosis, and therapy of infectious and inflammatory diseases. These aims are being addressed by a multidisciplinary team that combines basic scientists and clinical experts with different degrees of specialization, and that resorts to advanced cellular and animal models of disease and human patients enrolled in national and international consortia.

Scientific Highlights

(1) Feys S, Gonçalves SM, Khan M, Choi S, Boeckx B, Chatelain D, Cunha C, Debaveye Y, Hermans G, Hertoghs M, Humblet-Baron S, Jacobs C, Lagrou K, Marcelis L, Maizel J, Meersseman P, Nyga R, Seldeslachts L, Starick MR, Thevissen K, Vandenbriele C, Vanderbeke L, Vande Velde G, Van Regenmortel N, Vanstapel A, Vanmassenhove S, Wilmer A, Van De Veerdonk FL, De Hertogh G, Mombaerts P, Lambrechts D, Carvalho A, Van Weyenbergh J, Wauters J. “Lung epithelial and myeloid innate immunity in influenza-associated or COVID-19-associated pulmonary aspergillosis: an observational study”. Lancet Respir Med. 2022; in press (2) Hoenigl M, Seidel D, Sprute R, Cunha C, Oliverio M, Goldman GH, Ibrahim AS, Carvalho A. “COVID-19-associated fungal infections”. Nat Microbiol. 2022; 7(8):1127-1140; (2) Gonçales RA, Bastos HN, Duarte-Oliveira C, Antunes D, Sokhatska O, Jacob M, Rolo R, Campos CF, Sasaki SD, Donato A, Mapelli SN, Costa S, Souto Moura C, Delgado L, Morais A, Torrado E, van de Veerdonk FL, Weichhart T, Lambris JD, Silvestre R, Garlanda C, Mantovani A, Cunha C, Carvalho A. “Pentraxin 3 inhibits complement-mediated macrophage activation to restrain granuloma formation in sarcoidosis“. Am J Respir Crit Care Med. 2022; epub; (4) Gonçalves SM, Antunes D, Leite L, Mercier T, Horst RT, Vieira J, Espada E, Pinho Vaz C, Branca R, Campilho F, Freitas F, Ligeiro D, Marques A, van de Veerdonk FL, Joosten LAB, Lagrou K, Maertens J, Netea MG, Lacerda JF, Campos A Jr, Cunha C, Carvalho A. “Genetic variation in PFKFB3 impairs antifungal immunometabolic responses and predisposes to invasive pulmonary aspergillosis”. mBio. 2021; 12(3):e0036921; (5) Gonçalves SM, Duarte-Oliveira C, Campos CF, Aimanianda V, Ter Horst R, Leite L, Mercier T, Pereira P, Fernández-García M, Antunes D, Rodrigues CS, Barbosa-Matos C, Gaifem J, Mesquita I, Marques A, Osório NS, Torrado E, Rodrigues F, Costa S, Joosten LA, Lagrou K, Maertens J, Lacerda JF, Campos A Jr, Brown GD, Brakhage AA, Barbas C, Silvestre R, van de Veerdonk FL, Chamilos G, Netea MG, Latgé JP, Cunha C, Carvalho A. “Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity”. Nat Commun. 2020; 11(1):2282; (6) Kyrmizi I, Ferreira H, Carvalho A, Figueroa JAL, Zarmpas P, Cunha C, Akoumianaki T, Stylianou K, Deepe GS Jr, Samonis G, Lacerda JF, Campos A Jr, Kontoyiannis DP, Mihalopoulos N, Kwon-Chung KJ, El-Benna J, Valsecchi I, Beauvais A, Brakhage AA, Neves NM, Latge JP, Chamilos G. “Calcium sequestration by fungal melanin inhibits calcium-calmodulin signalling to prevent LC3-associated phagocytosis”. Nat Microbiol. 2018; 3(7):791-803; (7) Stappers MHT, Clark AE, Aimanianda V, Bidula S, Reid DM, Asamaphan P, Hardison SE, Dambuza IM, Valsecchi I, Kerscher B, Plato A, Wallace CA, Yuecel R, Hebecker B, da Glória Teixeira Sousa M, Cunha C, Liu Y, Feizi T, Brakhage AA, Kwon-Chung KJ, Gow NAR, Zanda M, Piras M, Zanato C, Jaeger M, Netea MG, van de Veerdonk FL, Lacerda JF, Campos A, Carvalho A, Willment JA, Latgé JP, Brown GD. “Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus”. Nature. 2018; 555(7696):382-386; (8) Cunha C, Gonçalves SM, Duarte-Oliveira C, Leite L, Lagrou K, Marques A, Lupiañez CB, Mesquita I, Gaifem J, Barbosa AM, Pinho Vaz C, Branca R, Campilho F, Freitas F, Ligeiro D, Lass-Flörl C, Löffler J, Jurado M, Saraiva M, Kurzai O, Rodrigues F, Castro AG, Silvestre R, Sainz J, Maertens JA, Torrado E, Jacobsen ID, Lacerda JF, Campos A Jr, Carvalho A. “IL-10 overexpression predisposes to invasive aspergillosis by suppressing antifungal immunity”. J Allergy Clin Immunol. 2017; 140(3):867-870.e9; (9) Cunha C, Aversa F, Lacerda JF, Busca A, Kurzai O, Grube M, Löffler J, Maertens JA, Bell AS, Inforzato A, Barbati E, Almeida B, Santos e Sousa P, Barbui A, Potenza L, Caira M, Rodrigues F, Salvatori G, Pagano L, Luppi M, Mantovani A, Velardi A, Romani L, Carvalho A. “Genetic PTX3 deficiency and aspergillosis in stem-cell transplantation”. N Engl J Med. 2014; 370(5):421-32; (10) Zelante T, Iannitti RG, Cunha C, De Luca A, Giovannini G, Pieraccini G, Zecchi R, D’Angelo C, Massi-Benedetti C, Fallarino F, Carvalho A, Puccetti P, Romani L. “Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22”. Immunity. 2013; 39(2):372-85


Functional genomics of fungal disease

Genetic analysis of molecular and functional traits in immune cells, such as gene and protein expression and effector functions, offers a promising strategy for investigating phenotypic variation and dissecting the molecular mechanisms underlying propensity to infection.

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Host-fungus interaction and disease pathogenesis

The reprogramming of cellular metabolism is a fundamental mechanism whereby immune cells respond to infection. The sensing of microbial ligands by myeloid cells promotes dynamic changes in host cell metabolism to deliver a rapid source of energy to support…

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Lung microbiome and mucosal immunity

Recent studies have successfully implicated several factors in the susceptibility to fungal infection, but have provided little insight into the nature of the underlying biological mechanisms. We propose a multiomics approach to link deep clinical phenotyping…

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