Bárbara Coimbra

  • Reward
  • Aversion
  • Neuronal Circuits
  • Addiction
  • Laterodorsal Tegmentum
  • Brainstem
I am a researcher investigating how brain circuits compute value and drive motivated behaviour and how these mechanisms become biased in addiction. My research focuses on brainstem neuromodulatory control of mesolimbic circuitry, with a particular emphasis on the laterodorsal tegmentum (LDT) and its interactions with the nucleus accumbens (NAc), a key hub for reinforcement learning and reward-guided action selection.
My work combines circuit anatomy, behavioural assays, and in vivo recordings with causal manipulations to link neural dynamics to behaviour. We use projection- and cell-type-specific viral strategies, optogenetics, high-density multichannel electrophysiology and longitudinal monitoring of population activity using fibre photometry and miniscope calcium imaging in freely behaving mice. In parallel, we leverage genetically encoded biosensors to measure neuromodulatory signals in vivo and integrate computational analyses to reveal how circuit interactions evolve across behavioural states and drug exposure. My research aims to provide principled insight into how adaptive motivational states become maladaptive, contributing to vulnerability to substance use and other psychiatric disorders.

Bárbara Coimbra

  • Reward
  • Aversion
  • Neuronal Circuits
  • Addiction
  • Laterodorsal Tegmentum
  • Brainstem
I am a researcher investigating how brain circuits compute value and drive motivated behaviour and how these mechanisms become biased in addiction. My research focuses on brainstem neuromodulatory control of mesolimbic circuitry, with a particular emphasis on the laterodorsal tegmentum (LDT) and its interactions with the nucleus accumbens (NAc), a key hub for reinforcement learning and reward-guided action selection.
My work combines circuit anatomy, behavioural assays, and in vivo recordings with causal manipulations to link neural dynamics to behaviour. We use projection- and cell-type-specific viral strategies, optogenetics, high-density multichannel electrophysiology and longitudinal monitoring of population activity using fibre photometry and miniscope calcium imaging in freely behaving mice. In parallel, we leverage genetically encoded biosensors to measure neuromodulatory signals in vivo and integrate computational analyses to reveal how circuit interactions evolve across behavioural states and drug exposure. My research aims to provide principled insight into how adaptive motivational states become maladaptive, contributing to vulnerability to substance use and other psychiatric disorders.

Scientific Highlights

Awarded projects (recent):
1.Bial Foundation Project (PI) – 2025–2027, €60,000: LDT-NAc cholinergic dynamics in associative learning.
2.FCT Project (PI) – 2026–2028, €175,000: Brain on cocaine: LDT cholinergic projections to NAc and addiction-relevant plasticity.
Publications (as corresponding author):
1. Aguiar, L.A.A. et al. 2026. Adaptive changes of cholinergic projections to the nucleus accumbens bidirectionally mediate cocaine reinforcing effects. Nature Communications
2.Teixeira, E. et al. 2026. Experience-defined ensembles in the laterodorsal tegmentum encode motivational valence and causally modulate reward-seeking behaviour. Biorxiv
3. Bastos-Gonçalves, R. et al. 2024. The mesopontine tegmentum in reward and aversion: From cellular heterogeneityto behaviour. Neuroscience & Biobehavioral Reviews
Publications:
1. Coimbra, B. et al. 2019. Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors. Nature Communications
2. Coimbra, B. et al. 2021. Laterodorsal tegmentum-ventral tegmental area projections encode positive reinforcement signals. Journal of Neuroscience Research
3. Coimbra B, et al. 2017. Impairments in laterodorsal tegmentum to VTAprojections underlie glucocorticoid-triggered reward deficits. eLife
4. Domingues, A.V. et al. 2022. Prenatal glucocorticoid exposure alters effort decision making and triggers nucleus accumbens and anterior cingulate cortex functional changes. Transl Psychiatry
5. Domingues, A.V. et al. 2025. Dynamic representation of appetitive and aversive stimuli in nucleus accumbens shell D1- and D2-medium spiny neurons. Nature communications

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Projects

As Leader

Brainstem orchestration of cue-reward associations

The brain constantly integrates new sensory information, and associates environmental cues to outcomes, adjusting behavior to maximize reward and minimize unpleasant consequences. This process is critical for survival, and its dysregulation is a hallmark of…

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Projects

As Member