Scientific Highlights
Awarded projects (recent):
1.Bial Foundation Project (PI) – 2025–2027, €60,000: LDT-NAc cholinergic dynamics in associative learning.
2.FCT Project (PI) – 2026–2028, €175,000: Brain on cocaine: LDT cholinergic projections to NAc and addiction-relevant plasticity.
Publications (as corresponding author):
1. Aguiar, L.A.A. et al. 2026. Adaptive changes of cholinergic projections to the nucleus accumbens bidirectionally mediate cocaine reinforcing effects. Nature Communications
2.Teixeira, E. et al. 2026. Experience-defined ensembles in the laterodorsal tegmentum encode motivational valence and causally modulate reward-seeking behaviour. Biorxiv
3. Bastos-Gonçalves, R. et al. 2024. The mesopontine tegmentum in reward and aversion: From cellular heterogeneityto behaviour. Neuroscience & Biobehavioral Reviews
Publications:
1. Coimbra, B. et al. 2019. Role of laterodorsal tegmentum projections to nucleus accumbens in reward-related behaviors. Nature Communications
2. Coimbra, B. et al. 2021. Laterodorsal tegmentum-ventral tegmental area projections encode positive reinforcement signals. Journal of Neuroscience Research
3. Coimbra B, et al. 2017. Impairments in laterodorsal tegmentum to VTAprojections underlie glucocorticoid-triggered reward deficits. eLife
4. Domingues, A.V. et al. 2022. Prenatal glucocorticoid exposure alters effort decision making and triggers nucleus accumbens and anterior cingulate cortex functional changes. Transl Psychiatry
5. Domingues, A.V. et al. 2025. Dynamic representation of appetitive and aversive stimuli in nucleus accumbens shell D1- and D2-medium spiny neurons. Nature communications